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GenomicsEpigenome in brown and white adipose tissue
For comparative epigenomic analysis of brown fat and white fat in mice, H3K27ac and PolII ChIP-seq were performed in each depot. H3K27ac histone modification and PolII transcription profiles in mouse brown and white adipose tissues
ORGANISM(S): Mus musculus 
2015-02-10 | E-GEOD-63964 | biostudies-arrayexpress
TranscriptomicsWhite-to-brown metabolic conversion of human adipocytes by JAK inhibition
The rising incidence of obesity and related disorders such as diabetes and heart disease has focused considerable attention on the discovery of novel therapeutics. One promising approach has been to increase the number or activity of brown-like adipocytes in white adipose depots, as this has been...
ORGANISM(S): Homo sapiens 
2014-10-31 | E-GEOD-57896 | biostudies-arrayexpress
TranscriptomicsBrown Adipose Tissue Harbors a distinct subpopulation of regulatory T cells
Regulatory T (Treg) cells are critical determinants of both immune responses and metabolic control. Here we show that systemic ablation of Treg cells compromised the adaptation of whole-body energy expenditure to cold exposure, correlating with impairment in thermogenic marker gene expression and ma...
ORGANISM(S): Mus musculus 
2015-06-23 | E-GEOD-64909 | biostudies-arrayexpress
UnknownAkebia Saponin D Targeting Ubiquitin Carboxyl-Terminal Hydrolase 4 Promotes Peroxisome Proliferator-Activated Receptor Gamma Deubiquitination and Activation of Brown Adipose Tissue Thermogenesis in Obesity.
Not available
S-EPMC12521790 | biostudies-literature
ProteomicsFasting upregulates the monocarboxylate transporter Mct1 at the rat blood-brain barrier through Ppar d activation
Fasting is increasingly recognized as a potential therapeutic intervention in the field of neurology and psychiatry. However, its impact upon the blood-brain barrier (BBB), which strictly regulates the cerebral uptake of a wide range of endogenous compounds and drugs, is unknown. In this study we us...
ORGANISM(S): Cellular Organisms 
2024-08-15 | PXD044587 | JPOST Repository
TranscriptomicsVitamin D Prevents Cognitive Decline and Enhances Hippocampal Synaptic Function in Aging Rats
Vitamin D is an important calcium-regulating hormone with diverse functions in numerous tissues including the brain. Increasing evidence suggests that vitamin D may play a role in maintaining cognitive function and that vitamin D deficiency may accelerate age-related cognitive decline. Using aging...
ORGANISM(S): Rattus norvegicus 
2014-09-23 | E-GEOD-61326 | biostudies-arrayexpress
MetabolomicsDeficient Endoplasmic Reticulum-Mitochondrial Phosphatidylserine Transfer Causes Liver Disease
Non-alcoholic fatty liver is the most common liver disease worldwide. Here, we show that the mitochondrial protein mitofusin 2 (Mfn2) protects against liver disease. Reduced Mfn2 expression was detected in liver biopsies from patients with non-alcoholic steatohepatitis (NASH). Moreover, reduced Mfn2...
2018-01-25 | MTBLS600 | MetaboLights
TranscriptomicsTranscription profiling of rat identifies of a serum induced transcriptional signature associated with type 1 diabetes
Human type 1 diabetes (T1D) arises through autoimmunity towards the insulin-producing pancreatic β cells and is modeled by the BioBreeding (BB) rat. Factors associated with islet autoimmunity are dilute and difficult to directly measure in the periphery. Therefore, we previously utilized microarray...
ORGANISM(S): Rattus norvegicus 
2009-12-25 | E-GEOD-19537 | biostudies-arrayexpress
UnknownLeveraging the genetic correlation between traits improves the detection of epistasis in genome-wide association studies.
Not available
S-EPMC10484060 | biostudies-literature
UnknownBrown Adipose Tissue Controls Skeletal Muscle Function via the Secretion of Myostatin.
Not available
S-EPMC6170693 | biostudies-literature
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