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UnknownTwo-step regulation by matrix Gla protein in brown adipose cell differentiation.
Not available
S-EPMC10832489 | biostudies-literature
GenomicsGenome-wide localization maps of JMJD1A, SWI/SNF components, and PPAR? in brown adipocytes treated with isoproterenol
We analyzed ChIP-seq profiles for H3K4me3, H3K27ac, BRG1, ARID1A, PPAR? and JMJD1A and FAIRE-seq open chromatin profile in immortalized brown adipocytes (iBATs) treated with 1 ?M isporoterenol (ISO) or vehicle for 2 hr ChIP-seq profiles for H3K4me3, H3K27ac, BRG1, ARID1A, PPAR? and JMJD1A and FAIRE-...
ORGANISM(S): Mus musculus 
2015-04-15 | E-GEOD-67586 | biostudies-arrayexpress
UnknownPembrolizumab 400 mg every 6 weeks as first-line therapy for advanced melanoma (KEYNOTE-555): Results from cohort B of an open-label, phase 1 study.
Not available
S-EPMC11556718 | biostudies-literature
TranscriptomicsCHD5, A Brain-Specific Chromatin Remodeling Enzyme, Regulates Expression Of Neuronal Genes.
CHD5 is frequently deleted in neuroblastoma, and appears to be a tumor suppressor gene; however, little is known about the role of CHD5. We found CHD5 mRNA was restricted to brain; by contrast most other remodeling ATPases were broadly expressed. CHD5 protein isolated from mouse brain was associat...
ORGANISM(S): Rattus norvegicus 
2011-09-21 | E-GEOD-27620 | biostudies-arrayexpress
TranscriptomicsMidbrain floor plate dopamine neurons from human ESCs efficiently engraft in murine and primate models of PD
Human pluripotent stem cells (hPSCs) are a promising source of cells for applications in regenerative medicine. Directed differentiation of hPSCs into specialized cells such as spinal motoneurons or midbrain dopamine (DA) neurons has been achieved. However the effective use of hPSCs for cell therap...
ORGANISM(S): Homo sapiens 
2011-11-07 | E-GEOD-32658 | biostudies-arrayexpress
GenomicsActivation of the chromatin-remodeling factor Smarca4/Brg1 cooperates with Olig2 to establish oligodendrocyte identity and control CNS myelination [ChIP-seq]
We investigate the role of Brg1 and Olig2 during oligodendrocyte differentiation by combining gene conditional knockout and next generation sequencing technology. We generate genome-wide maps of RNA polymerase II (RPolII), Brg1 (Smarca4), Olig2 and histone modifications in primary rat oligodendrocyt...
ORGANISM(S): Rattus norvegicus 
2013-01-20 | E-GEOD-42447 | biostudies-arrayexpress
TranscriptomicsRSC and ISW1 Chromatin Remodelers Display Functional and Chromatin-based Promoter Antagonism [nucleosome occupancy]
ISWI-family chromatin remodelers organize nucleosome arrays, while SWI/SNF-family remodelers (RSC) disorganize and eject nucleosomes, implying an antagonism that is largely unexplored in vivo. Here, we describe two independent genetic screens for rsc suppressors that yielded mutations in the promote...
ORGANISM(S): Saccharomyces cerevisiae 
2015-04-01 | E-GEOD-65590 | biostudies-arrayexpress
TranscriptomicsRNA-Seq of 293T cells depleted of U2AF-related proteins
Characterization of RNA processing events dependent on U2AF-related proteins PUF60 and RBM39. PUF60 (poly-U-binding factor 60 kDa, also known as FIR, Hfp or Ro-bp1) is a splicing factor homologous to the 65 kD subunit of the auxiliary factor of U2 small nuclear ribonucleoprotein (U2AF65). PUF60 has...
ORGANISM(S): Homo sapiens 
2018-05-25 | E-MTAB-6010 | biostudies-arrayexpress
TranscriptomicsThe structure and target identification of the tandem RRM of yeast Npl3 bound to RNA reveal a cooperative sequence-specific recognition and an RNA chaperone role in splicing
The conserved SR-like protein Npl3 promotes the splicing of diverse pre-mRNAs. However, the RNA sequence(s) recognized by the RNA Recognition Motifs (RRM1 & RRM2) of Npl3 during the splicing reaction remain elusive. Here, we developed a split-iCRAC approach in vivo to determine the consensus sequenc...
ORGANISM(S): Saccharomyces cerevisiae 
2022-12-01 | E-MTAB-11736 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of BRG1 response genes in human SW13 cells
BRG1 response genes in SW13 cells
ORGANISM(S): Homo sapiens 
2005-07-14 | E-SMDB-2974 | biostudies-arrayexpress
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