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GenomicsActivin/Nodal signalling controls divergent transcriptional networks in pluripotent and endoderm progenitors.
Activin/Nodal signalling is necessary to maintain pluripotency of human Embryonic Stem Cells (hESCs) and to induce their differentiation towards endoderm. However, the mechanisms by which Activin/Nodal signalling achieves these opposite functions remain unclear. To unravel these mechanisms, we exami...
ORGANISM(S): Homo sapiens 
2011-11-11 | E-GEOD-19461 | biostudies-arrayexpress
TranscriptomicsEffect of IL-1b treatment on cultured rat aortic smooth muscle cells
IL-1 plays an important role in atherosclerosis, and alters expression of a number of genes involved in atherosclerotic plaque development and progression. Smooth muscle cells play important roles in atherosclerotic plaque formation and stability, so this study was undertaken to determine the globa...
ORGANISM(S): Rattus norvegicus 
2012-12-31 | E-GEOD-21403 | biostudies-arrayexpress
ProteomicsLeishmania tarentolae axonemal components
This study was used to determine the components of the natively isolated Leishmania tarentolae axoneme. The sample used in this study had the membrane stripped in order to isolate solely the axonemal components.
ORGANISM(S): Leishmania tarentolae 
2025-05-19 | PXD059158 | Pride
Axoneme Cilia Leishmania Flagella 
TranscriptomicsMitochondrial carrier SLC25A34 links clock, diet, and temperature control of adipocyte lipid cycling
Transcriptome from immortalized murine brown adipocytes BMC. Cells were transfected with siRNA construct #1 or construct #2 (pool) or non-targeting control on day 3 of differentiation and harvested on day 7 of differentiation.
ORGANISM(S): Mus musculus 
2026-09-23 | E-MTAB-17577 | biostudies-arrayexpress
GenomicsGenome-wide Myb chromatin occupancy in murine myeloid progenitor cells
We report genome-wide pattern of Myb chromatin occupancy in vivo. We used ERMYB, a myeloid progenitor cell line derived by transformation of primary cells by ER-Myb fusion protein, as our model system. In these cells, activation of the ER-Myb fusion protein by estrogen is required to maintain a prol...
ORGANISM(S): Mus musculus 
2011-02-23 | E-GEOD-22095 | biostudies-arrayexpress
TranscriptomicsRNA sequencing of chicken limb distal mesenchyme cells to compare gene expression over time and in heterochronic grafted cells
Distal limb mesenchyme cells were collected from embryonic chickens at Hamburger Hamilton (HH) stages HH24, HH27, and HH29, and also from samples that had been grafted from HH27 to HH20 and left to develop for 24 hours (equivalent to HH24). Samples were collected in triplicate (with 10 distal tips p...
ORGANISM(S): Gallus gallus 
2018-04-20 | E-MTAB-6437 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human embryonic stems cells grown in chemically defined medium supplemented with Activen and FGF or FGF2 and SB431542 to identify genes controlled by Activin/Nodal signalling
Human Embryonic Stem Cells (hESC) grown in chemically defined medium (CDM) supplemented with Activin and FGF were compared to hESCs grown for 48 hours in CDM supplemented with FGF2 and SB431542, an inhibitor of Activin/Nodal signalling. The objective of this experiment was to discover the identity o...
ORGANISM(S): Homo sapiens 
2009-03-14 | E-MEXP-1741 | biostudies-arrayexpress
TranscriptomicsVallier 3day endoderm
Transcriptional profiling of H9 human embryonic stem cells differentiated towards early endoderm over 72 hours in chemically defined media.
ORGANISM(S): Homo sapiens 
2011-01-26 | E-MTAB-467 | biostudies-arrayexpress
GenomicsPluripotency Factors Regulate Definitive Endoderm Specification through Eomesodermin
Understanding the molecular mechanisms controlling early cell fate decisions in mammals is a major objective towards the development of robust methods for the differentiation of human pluripotent stem cells into clinically relevant cell types. Here, we used human embryonic stem cells (hESCs) to stud...
ORGANISM(S): Homo sapiens 
2011-01-25 | E-GEOD-26097 | biostudies-arrayexpress
TranscriptomicsExposure to Cobalt Causes Transcriptomic and Proteomic Changes in Two Rat Liver Derived Cell Lines
Cobalt is a transition group metal present in trace amounts in the human diet, but in larger doses it can be acutely toxic or cause adverse health effects in chronic, long term exposures. Its use in many industrial processes and alloys worldwide presents opportunities for occupational exposures, as ...
ORGANISM(S): Rattus norvegicus 
2013-12-01 | E-GEOD-51207 | biostudies-arrayexpress
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