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ProteomicsEPAC1 enhances energy expenditure by selectively inducing brown and beige adipose tissue growth
Brown adipose tissue (BAT) is a central thermogenic organ that enhances energy expenditure (EE) and cardiometabolic health. However, regulators that specifically increase the number of thermogenic adipocytes are still an unmet need. Here, we show by phosphoproteomics that cAMP activates distinct sig...
ORGANISM(S): Mus musculus (Mouse) 
2023-11-11 | PXD046709 | Pride
Brown adipocyte Epac 
ProteomicsApoptotic brown adipocytes enhance energy expenditure via SLC29A1-regulated extracellular inosine
Brown adipose tissue (BAT) dissipates energy and promotes cardio-metabolic health4. However, loss of BAT during obesity and aging is a principal hurdle for BAT-centered obesity therapies. So far not much is known about BAT apoptosis and signals released by apoptotic brown adipocytes. Here, untargete...
ORGANISM(S): Mus musculus (Mouse) 
2022-05-31 | PXD032153 | Pride
Bat Insoine 
UnknownSite-level factors affecting nursing home implementation of a personalized music intervention: Qualitative analyses from Music & Memory: A Pragmatic Trial for Nursing Home Residents with Alzheimer's Disease (METRIcAL).
Not available
S-EPMC11694521 | biostudies-literature
MetabolomicsRapid identification of species, sex and maturity by mass spectrometric analysis of animal faeces

BACKGROUND: We describe a new approach to the recovery of information from faecal samples, based on the analysis of the molecular signature generated by rapid evaporative ionisation mass spectrometry (REIMS).

RESULTS: Faecal pellets from five different r...

2022-02-03 | MTBLS1095 | MetaboLights
TranscriptomicsTranscription profiling of rat heart tissue samples from animals undergoing different exercise regimens
The interaction of genetics and environment play a major role in health and disease. Therefore, modeling experiments to investigate gene-environment interaction in a laboratory setting would provide the opportunity to gain mechanistic insight under controlled conditions. In laboratory research it is...
ORGANISM(S): Rattus norvegicus 
2007-10-10 | E-GEOD-2690 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat pooled untreated cultured ovaries vs. pooled cultured ovaries treated with anti-Mullerian hormone
The oocytes found within the primordial follicles of mammalian ovaries remain quiescent for months to years until they receive the appropriate signals to undergo the primordial to primary follicle transition and initiate folliculogenesis. The molecular mechanisms and extracellular signaling factors ...
ORGANISM(S): Rattus norvegicus 
2008-04-07 | E-GEOD-10557 | biostudies-arrayexpress
TranscriptomicsProtein Arginine Methyltransferase 6 dependent gene expression and splicing: Association with breast cancer outcomes
Protein arginine methyltransferase-6 (PRMT6) regulates steroid-dependent transcription and alternative splicing, and is implicated in endocrine system development and function, cell death, cell cycle, gene expression and cancer. Despite its role in these processes, little is known about its function...
ORGANISM(S): Homo sapiens 
2012-08-01 | E-GEOD-36542 | biostudies-arrayexpress
Unknownm6A mRNA Methylation Regulates Early Pancreatic Cell Differentiation
Not available
S-SCDT-10_1038-S44318-024-00213-2 | biostudies-other
GenomicsWhole Exome Sequencing of Chronic Lymphocytic Leukemia

The somatic genetic basis of chronic lymphocytic leukemia (CLL), a common and clinically heterogenous adult leukemia, remains poorly understood. Massively parallel sequencing technology now provides a method for systematic discovery of genetic alterations that underlie disease, and for uncovering...

phs000435.v1.p1 | EGA
GenomicsUC
WTCCC2 project Ulcerative Colitis (UC) samples
EGAD00000000025 | EGA
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