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TranscriptomicsTranscription profiling of human HMVEC cells treated with vascular endothelial growth factor, anthrax edema toxin, and an Epac activator
Human microvascular endothelial cells (HMVEC) treated with vascular endothelial growth factor (VEGF), Antrhax Edema Toxin (ET), or the Epac activator, 8-pCPT-2'-O-Me-cAMP (8CPT); Human microvascular endothelial cells (HMVEC) were treated with VEGF alone or VEGF in combination with either the the Epa...
ORGANISM(S): Homo sapiens 
2009-09-13 | E-GEOD-17777 | biostudies-arrayexpress
ProteomicsMice liver tissue LC-MSMS EPAC
We employed mouse models with targeted deletion of the genes encoding Epac1 (Rapgef3) and Epac2 (Rapgef4) in combination with 2/3 partial hepatectomy to investigate the functional roles of Epac1 and Epac2 in liver. Proteomic analysis of liver tissue before and 36h after hepatectomy revealed changes ...
ORGANISM(S): Mus musculus (Mouse) 
2019-09-12 | PXD006165 | Pride
Lc-msms Hepatectomy Liver tissue Mice Epac 
GenomicsThioredoxin interacting protein (TXNIP), a redox regulator, mediates the EPAC-RAP1 signaling dependency of primary melanoma
Thioredoxin interacting protein (TXNIP), a redox regulator, mediates the EPAC-RAP1 signaling dependency of primary melanoma
PRJNA1423672 | ENA
TranscriptomicsHMVEC cells treated with vascular endothelial growth factor, anthrax edema toxin, and an Epac activator
Human microvascular endothelial cells (HMVEC) treated with vascular endothelial growth factor (VEGF), Antrhax Edema Toxin (ET), or the Epac activator, 8-pCPT-2'-O-Me-cAMP (8CPT) Human microvascular endothelial cells (HMVEC) were treated with VEGF alone or VEGF in combination with either the the Epac...
ORGANISM(S): Homo sapiens 
2009-08-25 | GSE17777 | GEO
UnknownEpac-inhibitors: facts and artefacts.
Not available
S-EPMC3805970 | biostudies-literature
UnknownDetecting cAMP-induced Epac activation by fluorescence resonance energy transfer: Epac as a novel cAMP indicator.
Not available
S-EPMC1299185 | biostudies-literature
UnknownEPAC Regulates Melanoma Growth by Stimulating mTORC1 Signaling and Loss of EPAC Signaling Dependence Correlates with Melanoma Progression.
Not available
S-EPMC9532357 | biostudies-literature
TranscriptomicsThioredoxin interacting protein (TXNIP), a redox regulator, mediates the EPAC-RAP1 signaling dependency of primary melanoma
RAP guanine exchange factors EPAC1/2 (Exchange Protein Activated by cyclic AMP) are important signaling proteins. EPACs are important for the growth of cutaneous primary melanoma and loss of dependency on EPACs is associated with melanoma metastatic progression. In this study, employing transformed ...
ORGANISM(S): Homo sapiens 
2026-07-29 | GSE319527 | GEO
UnknownEpac: new emerging cAMP-binding protein.
Not available
S-EPMC8016657 | biostudies-literature
UnknownEPAC proteins transduce diverse cellular actions of cAMP.
Not available
S-EPMC2795248 | biostudies-literature
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