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ProteomicsSmall molecule inhibition of ubiquitin C-terminal hydrolase L1 alters cell metabolism proteins and exerts anti- or pro-tumorigenic effects contingent upon chemosensitivity status in high grade serous ovarian cancer
In the current investigation, we sought to characterize the implications of UCHL1 small molecule inhibition in both chemosensitive and chemoresistant HGSOC cells, generating an unprecedented understanding of the clinically relevant implications of targeting UCHL1.
ORGANISM(S): Homo sapiens (Human) 
2025-02-26 | PXD060691 | Pride
Human Ovarian cancer Lc-ms Small molecule inhibitor 
Unknown1281. Longitudinal and Spatial Variation in the Human Microbiome in a Phase 2a Clinical Study of Gepotidacin in Adult Females with Uncomplicated Urinary Tract Infection
Not available
S-EPMC7776697 | biostudies-literature
TranscriptomicsLNCaP prostate cancer cell lines overexpressing wild-type or GARRPR-mutant Bag-1L
The BF-3 pocket of the androgen receptor (AR) has been identified as an allosteric modulator of the transactivation function of the AR. We now demonstrate that a duplicated GARRPR motif at the N-terminus of the cochaperone Bag-1L functions through this BF-3 domain. Amino acid exchanges in these two ...
ORGANISM(S): Homo sapiens 
2014-02-18 | E-GEOD-51524 | biostudies-arrayexpress
TranscriptomicsGene Expression in the Rice Blast Fungus, Magnaporthe grisea, During Nitrogen Starvation
This experiment was designed to analyze transcriptional changes that occur when the fungal plant pathogen M. grisea is shifted from a complete media to a nitrogen-starved media. Comparisons were made in the following way between fungal mycelial grown in minimal media supplemented with a nitrogen sou...
ORGANISM(S): Magnaporthe grisea 
2010-07-01 | E-GEOD-2716 | biostudies-arrayexpress
UnknownEvaluating AI-Generated Geriatric Case Studies for Interprofessional Education: Systematic Analysis Across 5 Platforms.
Not available
S-EPMC12905562 | biostudies-literature
UnknownDeveloping a Memory and Communication App for Persons Living With Dementia: An 8-Step Process.
Not available
S-EPMC10131779 | biostudies-literature
OtherComparative phosphoproteomic analysis of mammalian glomeruli reveals conserved podocin C-terminal phosphorylation as a determinant of slit diaphragm complex architecture.
Data from ProteomeXchange, PXD ID: PXD001005. Experiment: 130104MaRiS_TpD, file: 0089-130104MaRiS04TpD.mzml. Published as part of Proteomics. 2014 Nov 25 . From the Abstract: {{i}} Glomerular biology is dependent on tightly controlled signal transduction networks that control phosphorylation of sig...
ORGANISM(S): Rat 
GPM32320007078 | GPMDB
Resource Reanalysis 
ProteomicsSas20 is a highly flexible starch-binding protein in the Ruminococcus bromii cell-surface amylosome
Ruminococcus bromii is a keystone species in the human gut that has the rare ability to degrade dietary resistant starch (RS). This bacterium secretes a suite of starch-active proteins that work together within larger complexes called amylosomes that allow R. bromii to adhere to and degrade RS. Sas2...
ORGANISM(S): Bacteria Ruminococcus bromii L2-63 
2022-06-09 | PXD032013 | Pride
R. bromii 
TranscriptomicsSAGE profile of rat hippocampus mRNA from Wistar rats
SAGE profile of rat hippocampus mRNA from Wistar rats This GEO Series was created by the GEO staff as part of a cleanup effort to ensure that all GEO Samples are included within a Series entry.
ORGANISM(S): Rattus norvegicus 
2010-12-01 | E-GEOD-25750 | biostudies-arrayexpress
TranscriptomicsIdentification of Adaptive mutations in the influenza A virus non-structural 1 gene that increase cytoplasmic localization and differentially regulate host gene expression
The NS1 protein of influenza A virus (IAV) is a multifunctional virulence factor. Mouse adaptive mutations in the NS1 protein of the human isolate A/Hong Kong/1/1968(H3N2) (HK) have been previously reported to increase virulence, viral fitness, and interferon antagonism, but differ in binding to pos...
ORGANISM(S): Mus musculus 
2013-06-22 | E-GEOD-48217 | biostudies-arrayexpress
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