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MetabolomicsAngiopoietin-like 4 governs diurnal lipoprotein lipase activity in brown adipose tissue.

OBJECTIVE: Brown adipose tissue (BAT) burns fatty acids (FAs) to produce heat, and shows diurnal oscillation in glucose and triglyceride (TG)-derived FA-uptake, peaking around wakening. Here we aimed to gain insight in the diurnal regulation of metabolic BAT activity.

2023-11-15 | MTBLS4082 | MetaboLights
TranscriptomicsmRNA-seq based gene expression profiling of differentiating murine brown preadipocytes (IBA)
mRNA-sequencing was used to profile temporal changes in gene expression during in vitro differentiation of IBA at five different time points: Day 0 (confluence), 2h (post induction), Day 1, Day 2 and Day 4 (mature brown adipocytes), performed in two biological replicates (with two technical replicat...
ORGANISM(S): Mus musculus 
2017-10-14 | E-MTAB-5160 | biostudies-arrayexpress
GenomicsChIP-seq based genome wide profiling of the histone mark H3K27ac and transcription factor Nuclear Factor 1 (NFI) in a differentiating murine brown preadipocyte cell line (IBA)
ChIP sequencing was used to generate genome-wide maps of the histone mark H3K27ac during in vitro differentiation of a murine brown preadipocyte cell line (IBA) at five different time points, in two biological replicates: Day 0 (confluence), 2h (post induction), Day 1, Day 2 and Day 4 (mature brown ...
ORGANISM(S): Mus musculus 
2017-09-21 | E-MTAB-5159 | biostudies-arrayexpress
TranscriptomicsBarcoded mRNA-seq of murine brown preadipocytes (IBA) upon transcriptomic perturbation
Loss of function assays were performed in differentiating IBAs using short hairpin RNAs (shRNAs) against a set of candidate transcription factors: NFIA, DBP, HOXA4, ZFP467, SOX18, ELF3, YBX2 and PPARa. Gene expression profiles of the perturbed and non perturbed (controls including non transduced cel...
ORGANISM(S): Mus musculus 
2017-09-21 | E-MTAB-5161 | biostudies-arrayexpress
TranscriptomicsRemodeling of Brown and White Adipose Tissue by NT-PGC-1α-Mediated Gene Regulation
The β-adrenergic receptor signaling pathway is a major component of adaptive thermogenesis in brown and white adipose tissue during cold acclimation. The β-AR activation highly induces transcriptional coactivator PGC-1α and its splice variant N-terminal (NT)-PGC-1α, promoting the transcription progr...
ORGANISM(S): Mus musculus 
2015-08-07 | E-GEOD-71774 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat esophagus treated with N-nitrosomethylbenzylamine to identify the effects of phenylethyl isothiocyanate on N-nitrosomethylbenzylamine-induced cytotoxicity
To date, there is little information on early molecular events in the development of N-nitrosomethylbenzylamine (NMBA) induced esophageal tumorigenesis and of the effects of chemopreventive agents on these events. In this study, we identified genes in rat esophagus that were differentially expressed...
ORGANISM(S): Rattus norvegicus 
2008-06-15 | E-GEOD-6917 | biostudies-arrayexpress
UnknownGenetic Monitoring of Brown Trout Released Into a Novel Environment: Establishment and Genetic Impact on Natural Populations.
Not available
S-EPMC11868033 | biostudies-literature
TranscriptomicsTranscription profiling of chord and interstitial regions of rat testes at gestational day 19 treated in utero with dibutylphthalate (DBP)
An experiment was performed to assess the effects on rats of in utero dibutylphthalate (DBP)-treatment on the transcriptome of whole fetal testes at gestational day 19.
ORGANISM(S): Rattus norvegicus 
2007-04-05 | E-TABM-201 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of heart during hypoxia of the Fawn Hooded Hypertensive (FHH) rat and FHH12BN consomic rat
Examination of gene expression changes during hypoxia of the Fawn Hooded Hypertensive (FHH) rat and FHH12BN consomic rat. FHH12BN rats are derived from introgression of chromosome 12 and from the Brown Norway (BN) rat into the FHH genetic background.
ORGANISM(S): Rattus norvegicus 
2006-09-15 | E-TIGR-111 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of lung from Dahl salt sensitive (SS) rats and SS4BN consomic rats during hypoxia treatment
Examination of gene expression changes during hypoxia of the Dahl salt sensative (SS) rat and SS4BN consomic rat. SS4BN rats are derived from introgression of chromosome 4 from Brown Norway (BN) rat into the genetic background.
ORGANISM(S): Rattus norvegicus 
2006-09-15 | E-TIGR-118 | biostudies-arrayexpress
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