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MetabolomicsUntargeted gas chromatography–mass spectrometry-based metabolomics analysis of kidney and liver tissue from the Lewis Polycystic Kidney rat
Polycystic kidney disease (PKD) encompasses a spectrum of inherited disorders that lead to end-stage renal disease (ESRD). There is no cure for PKD and current treatment options are limited to renal replacement therapy and transplantation. A better understanding of the pathobiology of PKD is needed ...
2023-01-26 | MTBLS748 | MetaboLights
UnknownSafety and Efficacy of Tucatinib, Letrozole, and Palbociclib in Patients with Previously Treated HR+/HER2+ Breast Cancer.
Not available
S-EPMC10722138 | biostudies-literature
TranscriptomicsTranscription profiling of human haematological neoplasias from blood samples and cell lines
Validation of a custom low density microarray. Gene expression differences were analysed in the following groups of blood samples and cell lines:
Two haematological neoplasia cell lines: U937 (promonocytic lymphoma) versus Jurkat (T leukemia).
Different types of haematological neoplasias: heal...
ORGANISM(S): Homo sapiens 
2007-01-31 | E-TABM-87 | biostudies-arrayexpress
TranscriptomicsExpression data from liver of young and old rats fed on different dietary fat sources, namely virgin olive, sunflower or fish oils
Since the liver is the central organ of metabolism, changes in diet have a great impact on this organ and overall on health with aging. It is well known that dietary fat source strongly influences many parameters of the hepatic mitochondria. These changes includes modification of lipid composition o...
ORGANISM(S): Rattus norvegicus 
2014-03-26 | E-GEOD-56166 | biostudies-arrayexpress
Transcriptomicsrat small intestine samples
Experiment description 1. Experimental design 1) Authors, laboratory, and contact: Xue-Lin Cui1, Patricia Soteropoulos2, Peter Tolias2, Ronaldo P. Ferraris1: 1Dept. of Pharmacology and Physiology, UMDNJ-New Jersey Medical School, Newark, NJ 07103-2714, 2Center for Applied Genomics, PHRI, 225 Warre...
ORGANISM(S): Rattus norvegicus 
2010-06-09 | E-GEOD-996 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of hepatocyes from Zucker fa/fa obese rats vs controls
Analysis of the gene signature of steatosis associated to obesity in hepatocytes of Zucker fa/fa obese rats and their controls; identifying target genes linked to steatosis progression. or Obesity and insulin resistance-associated steatosis can be a non-inflammatory condition affecting hepatocytes o...
ORGANISM(S): Rattus norvegicus 
2008-07-31 | E-MEXP-1414 | biostudies-arrayexpress
UnknownRegulation of autophagy-mediated pathways by diet, physical activity, and sleep in Alzheimer's disease.
Not available
S-EPMC12928064 | biostudies-literature
TranscriptomicsGene expression in 2,3-Pentanedione Induced Bronchiolitis Oblliterans
Fibrotic and nonfibrotic bronchial tissues were collected from lungs of pentandione exposed rats by laser capture microdissection. Analogous tissue was collected from air-exposed controls. Miroarray analysis revealed a number of DEGs Male Wistar Han rats were exposed to either air or 200 ppm 2,3-pen...
ORGANISM(S): Rattus norvegicus 
2015-03-03 | E-GEOD-52761 | biostudies-arrayexpress
UnknownHousing Assistance Programs and Adult Health in the United States.
Not available
S-EPMC5343706 | biostudies-literature
TranscriptomicsProtection from obesity and diabetes by blockade of TGF-beta/Smad3 signaling
Imbalances in glucose and energy homeostasis are at the core of the worldwide epidemic of obesity and diabetes. Here, we illustrate an important role of the TGF-beta/Smad3 signaling pathway in regulating glucose and energy homeostasis. Smad3 deficient mice are protected from diet-induced obesity and...
ORGANISM(S): Mus musculus 
2011-07-12 | E-GEOD-28598 | biostudies-arrayexpress
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