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TranscriptomicsTranscription profiling of rat 3Y1 embryonic fibroblasts to identify MUC1-induced transcriptional alterations
The MUC1 oncoprotein is aberrantly overexpressed in diverse human malignancies including breast and lung cancer. Although MUC1 modulates the activity of several transcription factors, there is no information regarding the effects of MUC1 on global gene expression patterns and the potential role of M...
ORGANISM(S): Rattus norvegicus 
2009-04-19 | E-GEOD-14337 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat heart after ischaemia reperfusion injury and then treatment with saline, urocortin I, urocortin II or tempol
The transcriptional effects of urocortin I, urocortin II and tempol were compared to saline treatment in a rat model of in vivo coronary artery occlusion model of ischaemia/reperfusion injury of 25 min ischaemia and 2 hr reperfusion.
The treatment groups were as follows (i) sham operation or LAD...
ORGANISM(S): Rattus norvegicus 
2009-03-25 | E-MEXP-2098 | biostudies-arrayexpress
TranscriptomicsCorrelates of chronic stress and their influence on the development of substance use in a population-based cohort of young adults (OYSUP)
Background: We seek to understand correlates of chronic stress and their influence on the development of substance use in a population-based cohort of young adults (OYSUP). Methodology: We evaluated clinical features, salivary RNA metrics and differential expression of candidate genes in unfraction...
ORGANISM(S): Homo sapiens 
2012-06-15 | E-GEOD-27144 | biostudies-arrayexpress
TranscriptomicsExpression data from cyclically stretched engineered neonatal rat ventricuar myocyte (NRVM) tissues
Mechanical overload in the heart induces pathological remodeling that typcially leads to heart failure. We sought to build an in vitro model of heart failure by applying cyclic stretch to engineered isotropic (iso) and anisotropic (aniso) NRVM tissues. We used micoarrays to determine the effects of ...
ORGANISM(S): Rattus norvegicus 
2013-01-30 | E-GEOD-43846 | biostudies-arrayexpress
TranscriptomicsKidney development time course
Array Design; Mouse Compugen 22K Spotted Oligo Author; Sean Grimmond Common Reference (Yes/No, ID); Yes Mouse universal Reference (Stratagene) Concentration; 100 Data processing/normalization; Lowess Normalisation GeneSpring) Developmental Stage; embryonic Diseased/Normal; normal Dye Swap; red/green...
ORGANISM(S): Mus musculus 
2010-06-09 | E-GEOD-2282 | biostudies-arrayexpress
TranscriptomicsFollicular lymphoma and normal lymphoid tissue comparisons
20 FL lymph node samples from 16 patients and four normal lymphoid tissues (two tonsil and two spleen) from four different patient. Data can be viewed on the supplemental website at http://genome-www.stanford.edu/rituximab/. Set of arrays organized by shared biological context, such as organism, tu...
ORGANISM(S): Homo sapiens 
2005-11-22 | E-GEOD-3646 | biostudies-arrayexpress
TranscriptomicsAnalysis of gene expression in QKI knockdown CG-4 cells
QKI is required for myelin formation in the verterbrate brain. It functions by binding RNA and regulating its stability, translation, and/or aternative splicing. We have used Affymetrix exon arrays to assess changes in gene expression in response to QKI knockdown on an exon level in rat CG-4 oligod...
ORGANISM(S): Rattus norvegicus 
2011-01-20 | E-GEOD-26716 | biostudies-arrayexpress
TranscriptomicsRNA-seq of mouse astrocytes in monoculture and co-cultured with rat neurons (both inactive and active).
Neurons induce a dramatic transformation in developing astrocytes, causing them to develop a complex stellate morphology resembling their appearance in vivo. However, the transcriptional changes that accompany this transformation are not known, nor are the signalling mechanisms responsible. Similarl...
ORGANISM(S): Rattus norvegicus 
2017-05-02 | E-MTAB-5514 | biostudies-arrayexpress
TranscriptomicsTranscriptome-wide microRNA expression of the heart of neonatal rats with polygenic cardiac hypetrophy
Identification of microRNAs differentially expressed between the neonatal heart of a genetic rat model of cardiac hypertrophy (the Hypertrophic Heart Rat, HHR) and the control (the Normal Heart Rat, NHR) using the Agilent Rat miRNA Microarray Kit Release 16.0. Neonatal (day 2) HHR and age-matched N...
ORGANISM(S): Rattus norvegicus 
2014-02-03 | E-GEOD-38710 | biostudies-arrayexpress
TranscriptomicsIntegrated transcriptomic and epigenomic analysis of primary human lung cell differentiation (Rat)
Analysis of gene expression during differentiation of alveolar epithelial type 2 (AT2) cells into AT1 cells. Timepoints taken at Day 0 (AT2 cell), Days 2, 4, and 6 in culture (differentiating) and Day 8 in culture (AT1-like cells). 1ug of RNA was subjected to cRNA conversion using Illumina TotalPrep...
ORGANISM(S): Rattus norvegicus 
2013-04-15 | E-GEOD-38570 | biostudies-arrayexpress
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