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TranscriptomicsTranscription profiling of rat kidney samples following treatment with the corticosteroid methylprednisolone over several time intervals
Summary: To identify distinct temporal patterns of mRNA expression in the kidney of rats following a bolus dose of the corticosteroid methylprednisolone. Hypothesis: That prednisone pharmacodynamics can be derived from expression profiling data.
ORGANISM(S): Rattus norvegicus 
2007-09-13 | E-GEOD-1721 | biostudies-arrayexpress
UnknownHealthcare worker attitudes on routine non-urological preoperative urine cultures: a qualitative assessment.

Objective

Many preoperative urine cultures are of low value and may even lead to patient harms. This study sought to understand practices around ordering preoperative urine cultures and prescribing antibiotic treatment.

Design

Open-ended, semi-structured qualitative interviews.

Set...

S-EPMC11611506 | biostudies-literature
UnknownUnique expansion of IL-21+ Tfh and Tph cells under control of ICOS identifies Sjogren's syndrome with ectopic germinal centres and MALT lymphoma.

Objectives

To explore the relevance of T-follicular-helper (Tfh) and pathogenic peripheral-helper T-cells (Tph) in promoting ectopic lymphoid structures (ELS) and B-cell mucosa-associated lymphoid tissue (MALT) lymphomas (MALT-L) in Sjögren's syndrome (SS) patients.

Methods

Salivary g...
S-EPMC7677495 | biostudies-literature
UnknownUpdated guidelines for gene nomenclature in wheat.

Key message

Here, we provide an updated set of guidelines for naming genes in wheat that has been endorsed by the wheat research community. The last decade has seen a proliferation in genomic resources for wheat, including reference- and pan-genome assemblies with gene annotations, which pro...
S-EPMC10036449 | biostudies-literature
UnknownThe mediational effects of FDG hypometabolism on the association between cerebrospinal fluid biomarkers and neurocognitive function.
Positive cerebrospinal fluid (CSF) biomarkers of tau and amyloid beta42 suggest possible active underlying Alzheimer's disease (AD) including neurometabolic dysfunction and neurodegeneration leading to eventual cognitive decline. But the temporal relationship between CSF, imaging markers of neural f...
S-EPMC4262609 | biostudies-literature
UnknownGenome-Wide Interaction Analysis with DASH Diet Score Identified Novel Loci for Systolic Blood Pressure.

Objective

We examined interactions between genotype and a Dietary Approaches to Stop Hypertension (DASH) diet score in relation to systolic blood pressure (SBP).

Methods

We analyzed up to 9,420,585 biallelic imputed single nucleotide polymorphisms (SNPs) in up to 127,282 individuals o...
S-EPMC10659476 | biostudies-literature
UnknownGenome-Wide Interaction Analysis With DASH Diet Score Identified Novel Loci for Systolic Blood Pressure.

Background

The Dietary Approaches to Stop Hypertension (DASH) diet score lowers blood pressure (BP). We examined interactions between genotype and the DASH diet score in relation to systolic BP.

Methods

We analyzed up to 9 420 585 single nucleotide polymorphisms in up to 127 282 indiv...
S-EPMC10922535 | biostudies-literature
UnknownImpact of essential genes on the success of genome editing experiments generating 3313 new genetically engineered mouse lines.
The International Mouse Phenotyping Consortium (IMPC) systematically produces and phenotypes mouse lines with presumptive null mutations to provide insight into gene function. The IMPC now uses the programmable RNA-guided nuclease Cas9 for its increased capacity and flexibility to efficiently genera...
S-EPMC11443006 | biostudies-literature
UnknownUnexpected frequency of the pathogenic AR CAG repeat expansion in the general population.
CAG repeat expansions in exon 1 of the AR gene on the X chromosome cause spinal and bulbar muscular atrophy, a male-specific progressive neuromuscular disorder associated with a variety of extra-neurological symptoms. The disease has a reported male prevalence of approximately 1:30 000 or less, but ...
S-EPMC10316764 | biostudies-literature
UnknownWhole-genome sequencing reveals host factors underlying critical COVID-19.
Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2-4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enab...
S-EPMC9259496 | biostudies-literature
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