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MetabolomicsBrown and beige adipose tissue regulate systemic metabolism through a metabolite interorgan signaling axis
Brown and beige adipose tissue are emerging as distinct endocrine organs. These tissues are functionally associated with skeletal muscle, adipose tissue metabolism and systemic energy expenditure, suggesting an interorgan signaling network. Using metabolomics, we identify 3-methyl-2-oxovaleric acid,...
2022-03-03 | MTBLS2436 | MetaboLights
UnknownThe Energy System Transformation Needed to Achieve the U.S. Long-Term Strategy.
Not available
S-EPMC9454374 | biostudies-literature
ProteomicsDeletion of the mitochondrial peptidase miPEP in adipose tissue protects against obesity and insulin resistance by increasing adaptive thermogenesis
Mitochondria are pivotal for cellular metabolism, serving as sources and targets of nutrient intermediates from converging metabolic pathways. Here, we demonstrate that insulin resistance leads to a marked alteration in the mitochondrial proteome of adipocytes. Analysis across multiple insulin resis...
ORGANISM(S): Mus musculus (Mouse) 
2024-08-10 | PXD051606 | Pride
Insulin resistance Mipep Thermogenesis Adipose Mitochondria 
ProteomicsTec kinase deficiency in macrophages
Previous work has shown conflicting roles for Tec family kinases in regulation of Toll-like receptor (TLR)-dependent signalling in myeloid cells. In the present study, we performed a detailed investigation of the role of Btk and Tec kinases in regulating TLR signalling in several types of primary mu...
ORGANISM(S): Mus musculus (Mouse) 
2018-10-24 | PXD002031 | Pride
Tec kinase macrophage 
UnknownThermal and Osmotic Tolerance of 'Irukandji' Polyps: Cubozoa; Carukia barnesi.
Not available
S-EPMC4956319 | biostudies-literature
GenomicsChIP-seq analysis of the cAMP binding protein (CRP) in Enteroaggregative Escherichia coli 042
ChIP-seq experiments were carried out in Enteroaggregative Escherichia coli 042. Wildtype 042 cells were grown to mid-log phase in LB medium, before being crosslinked with 1% formaldehyde and sonicated to lyse cells and shear DNA. Immunocomplexes were established using anti-FLAG antibodies. The immu...
ORGANISM(S): Escherichia coli 
2025-07-09 | E-MTAB-14748 | biostudies-arrayexpress
UnknownEvaluation of IL12B as a candidate type I diabetes susceptibility gene using data from the Type I Diabetes Genetics Consortium.
Not available
S-EPMC2805152 | biostudies-literature
Unknown<i>MRE11A</i> Isoform Expression Associated with Outcome Following Radiotherapy in Muscle-Invasive Bladder Cancer does not Alter Cell Survival and DNA Double-Strand Break Repair Following Ionising Radiation.
Not available
S-EPMC6949534 | biostudies-literature
UnknownGreenspace and human health: An umbrella review.
Not available
S-EPMC8479545 | biostudies-literature
ProteomicsLysine Acetylation Dynamics - The Tec Kinase-Regulated Phosphoproteome Reveals a Mechanism for the Regulation of Inhibitory Signals in Murine Macrophages
Cultured carcinoma cells were stimulated with growth factors and lysine acetylation and/or tyrosine phosphorylation dynamics were quantified.
ORGANISM(S): Homo sapiens (Human) 
2016-04-11 | PXD002013 | Pride
Tyrosine phosphorylation Lysine acetylation 
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