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ProteomicsDeletion of the mitochondrial peptidase miPEP in adipose tissue protects against obesity and insulin resistance by increasing adaptive thermogenesis
Mitochondria are pivotal for cellular metabolism, serving as sources and targets of nutrient intermediates from converging metabolic pathways. Here, we demonstrate that insulin resistance leads to a marked alteration in the mitochondrial proteome of adipocytes. Analysis across multiple insulin resis...
ORGANISM(S): Mus musculus (Mouse) 
2024-08-10 | PXD051606 | Pride
Insulin resistance Mipep Thermogenesis Adipose Mitochondria 
UnknownIdentification of a novel MIPEP splice variant with altered substrate-binding properties.
Not available
S-EPMC12605189 | biostudies-literature
UnknownDeletion of miPEP in adipocytes protects against obesity and insulin resistance by boosting muscle metabolism.
Not available
S-EPMC11292358 | biostudies-literature
UnknownESF1 and MIPEP proteins promote estrogen receptor-positive breast cancer proliferation and are associated with patient prognosis.
Not available
S-EPMC11247778 | biostudies-literature
UnknownCo-overexpression of the caloric restriction-induced mitochondrial factors PGC-1α and MIPEP upregulates Phospho1 expression in adipocytes.
Not available
S-EPMC12485865 | biostudies-literature
UnknownCase report: Rare novel MIPEP compound heterozygous variants presenting with hypertrophic cardiomyopathy, severe lactic acidosis and hypotonia in a Chinese infant.
Not available
S-EPMC9884671 | biostudies-literature
TranscriptomicsDisordered maturation of mitochondrial matrix proteins in adipose tissue leads to local and systemic metabolic and inflammatory derangements in adipocyte-specific Mipep knockout mice
Most mitochondrial matrix proteins encoded in the nuclear genome are synthesized in the cytoplasm. These proteins subsequently undergo maturation through the cleavage of a signal sequence at the N-terminus by one or two mitochondrial signal peptidases, which is essential for their function within mi...
ORGANISM(S): Mus musculus 
2025-04-23 | GSE282147 | GEO
GenomicsDisordered maturation of mitochondrial matrix proteins in adipose tissue leads to local and systemic metabolic and inflammatory derangements in adipocyte-specific Mipep knockout mice
Disordered maturation of mitochondrial matrix proteins in adipose tissue leads to local and systemic metabolic and inflammatory derangements in adipocyte-specific Mipep knockout mice
PRJNA1187468 | ENA
UnknownMIPEP recessive variants cause a syndrome of left ventricular non-compaction, hypotonia, and infantile death.
Not available
S-EPMC5088683 | biostudies-literature
UnknownRegulatory miPEP Open Reading Frames Contained in the Primary Transcripts of microRNAs.
Not available
S-EPMC9917039 | biostudies-literature
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