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GenomicsRNA-seq of primary islets in WT and Brsk2 transgenic mice
RNA-seq of primary islets in WT and Brsk2 transgenic mice
PRJNA637638 | ENA
ProteomicsMolecular characterization of BRSK2 and BRSK1 kinases as negative regulators of the NRF2 transcription factor
NFE2L2/NRF2 is a transcription factor and master regulator of the cellular antioxidant response. Aberrantly high NRF2-dependent transcription is recurrent in human cancer, resulting in increased cellular fitness, chemo-radiation resistance, metabolic reprogramming and immune evasion. NRF2 protein le...
ORGANISM(S): Homo sapiens (Human) 
2020-06-24 | PXD015884 | Pride
Sad-b Sad-a Brsk2 Ampk Nrf2 Mtor signaling Brsk1 Phosphoproteomics Antioxidant response 
GenomicsMolecular characterization of BRSK2 and BRSK1 kinases as negative regulators of the NRF2 transcription factor
Molecular characterization of BRSK2 and BRSK1 kinases as negative regulators of the NRF2 transcription factor
PRJNA578614 | ENA
TranscriptomicsMolecular characterization of BRSK2 and BRSK1 kinases as negative regulators of the NRF2 transcription factor
We found that the understudied Brain Specific Kinase 2 and 1 (BRSK2/1) proteins suppress NRF2-dependent transcription and NRF2 protein levels in a kinase-dependent fashion. Integrative phosphoproteomic screens, RNAseq profiling and follow-up validation studies revealed BRSK2/1-driven activation of A...
ORGANISM(S): Homo sapiens 
2019-11-16 | GSE139135 | GEO
UnknownDeleterious Variation in BRSK2 Associates with a Neurodevelopmental Disorder.
Not available
S-EPMC6451696 | biostudies-literature
UnknownGenetic variation reveals the therapeutic potential of BRSK2 in idiopathic pulmonary fibrosis.
Not available
S-EPMC11752817 | biostudies-literature
TranscriptomicsRNA-seq of primary islets in WT and Brsk2 transgenic mice
We investigated the underlying molecular mechanism of Brsk2's effects by comparing gene expression of whole primary islets isolated from Brsk2 TG mice and their control littermates by RNA sequencing.We chosed a four-day Dox administration and studied gene-expression differences resulting in hypergly...
ORGANISM(S): Mus musculus 
2020-06-06 | GSE151915 | GEO
UnknownBrain-selective kinase 2 (BRSK2) phosphorylation on PCTAIRE1 negatively regulates glucose-stimulated insulin secretion in pancreatic β-cells.
Not available
S-EPMC3436288 | biostudies-literature
UnknownBRSK2 plays a role in autophagy and cancer cell growth and survival under nutrient deprivation stress via the PIK3C3 pathway.
Not available
S-EPMC12630958 | biostudies-literature
UnknownBRSK2 in pancreatic β cells promotes hyperinsulinemia-coupled insulin resistance and its genetic variants are associated with human type 2 diabetes.
Not available
S-EPMC10782904 | biostudies-literature
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