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ProteomicsRedox Regulation of Brain Selective Kinases BRSK1/2: Implications for Dynamic Control of the Eukaryotic AMPK family through Cys-based mechanisms
In eukaryotes, protein kinase signaling is regulated by a diverse array of post-translational modifications (PTMs). While regulation by activation segment phosphorylation in Ser/Thr kinases is well understood, relatively little is known about how oxidation of cysteine (Cys) amino acids modulates cat...
ORGANISM(S): Homo sapiens (Human) 
2025-04-01 | PXD044990 | Pride
Brsk1 Redox Disulfide Brsk2 Cysteine 
UnknownHaploinsufficiency of brain-specific kinase BRSK1 causes epilepsy and neurodevelopmental disorders.
Not available
S-EPMC12779330 | biostudies-literature
ProteomicsMolecular characterization of BRSK2 and BRSK1 kinases as negative regulators of the NRF2 transcription factor
NFE2L2/NRF2 is a transcription factor and master regulator of the cellular antioxidant response. Aberrantly high NRF2-dependent transcription is recurrent in human cancer, resulting in increased cellular fitness, chemo-radiation resistance, metabolic reprogramming and immune evasion. NRF2 protein le...
ORGANISM(S): Homo sapiens (Human) 
2020-06-24 | PXD015884 | Pride
Sad-b Sad-a Brsk2 Ampk Nrf2 Mtor signaling Brsk1 Phosphoproteomics Antioxidant response 
GenomicsMolecular characterization of BRSK2 and BRSK1 kinases as negative regulators of the NRF2 transcription factor
Molecular characterization of BRSK2 and BRSK1 kinases as negative regulators of the NRF2 transcription factor
PRJNA578614 | ENA
TranscriptomicsMolecular characterization of BRSK2 and BRSK1 kinases as negative regulators of the NRF2 transcription factor
We found that the understudied Brain Specific Kinase 2 and 1 (BRSK2/1) proteins suppress NRF2-dependent transcription and NRF2 protein levels in a kinase-dependent fashion. Integrative phosphoproteomic screens, RNAseq profiling and follow-up validation studies revealed BRSK2/1-driven activation of A...
ORGANISM(S): Homo sapiens 
2019-11-16 | GSE139135 | GEO
UnknownESR1, HK3 and BRSK1 gene variants are associated with both age at natural menopause and premature ovarian failure.
Not available
S-EPMC3275465 | biostudies-literature
UnknownPossible modification of BRSK1 on the risk of alkylating chemotherapy-related reduced ovarian function.
Not available
S-EPMC7970730 | biostudies-literature
UnknownBoth Peripheral Blood and Urinary miR-195-5p, miR-192-3p, miR-328-5p and Their Target Genes PPM1A, RAB1A and BRSK1 May Be Potential Biomarkers for Membranous Nephropathy.
Not available
S-EPMC6427931 | biostudies-literature
UnknownInvestigating the regulation of brain-specific kinases 1 and 2 by phosphorylation.
Not available
S-EPMC3258900 | biostudies-literature
UnknownRelationship between BRSK1 rs12611091 variant and age at natural menopause based on physical activity.
Not available
S-EPMC7147414 | biostudies-literature
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