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GenomicsA unique chromatin signature uncovers early developmental enhancers in humans
Cell fate transitions involve integration of genomic information encoded by regulatory elements, such as enhancers, with the cellular environment. However, identification of the genomic sequences that control the earliest steps of human embryonic development represents a formidable challenge. Here w...
ORGANISM(S): Homo sapiens 
2010-12-15 | E-GEOD-24447 | biostudies-arrayexpress
UnknownPharmacological intervention of the FGF-PTH axis as a potential therapeutic for craniofacial ciliopathies.
Not available
S-EPMC9403750 | biostudies-literature
UnknownEpigenomic annotation of enhancers predicts transcriptional regulators of human neural crest.
Not available
S-EPMC3751405 | biostudies-literature
ProteomicsInability to switch from ARID1A-BAF to ARID1B-BAF impairs exit from pluripotency and commitment towards neural crest formation in ARID1B-related neurodevelopmental disorders
The BAF complex modulates chromatin accessibility. Specific BAF configurations have functional consequences, and subunit switches are essential for cell differentiation. ARID1B and its paralog ARID1A encode for mutually exclusive BAF subunits. De novo ARID1B haploinsufficient mutations cause a neuro...
ORGANISM(S): Homo sapiens (Human) 
2021-10-12 | PXD028557 | Pride
Cncc Arid1a Arid1b Ip Baf Lc-ms/ms 
UnknownOral enzyme combination therapy reduces systemic inflammation, urinary CTXII and pain in knee osteoarthritis: a proof-of-mechanism, randomised, crossover, double-blind, placebo-controlled trial
Not available
S-EPMC12352264 | biostudies-literature
UnknownAn inducible system to study the regulatory functions of GSX2 in human lateral ganglionic eminence-like progenitors.
Not available
S-EPMC12866604 | biostudies-literature
UnknownThe widely used Ucp1-Cre transgene elicits complex developmental and metabolic phenotypes.
Not available
S-EPMC11742029 | biostudies-literature
UnknownARID1A-BAF coordinates ZIC2 genomic occupancy for epithelial-to-mesenchymal transition in cranial neural crest specification.
Not available
S-EPMC11480806 | biostudies-literature
UnknownInability to switch from ARID1A-BAF to ARID1B-BAF impairs exit from pluripotency and commitment towards neural crest formation in ARID1B-related neurodevelopmental disorders.
Not available
S-EPMC8578637 | biostudies-literature
UnknownA distant global control region is essential for normal expression of anterior HOXA genes during mouse and human craniofacial development.
Not available
S-EPMC10762089 | biostudies-literature
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