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TranscriptomicsTranscriptomic response to aluminum stress in roots of aspen (Populus tremula L.)
Background: Solubilized aluminum (Al) is rhizotoxic and can be present in acid soils at levels that inhibit root growth. Acid soils are found throughout the world and often support forests. However, unlike in herbaceous plants, little is known about the mechanisms by which forest trees respond to an...
ORGANISM(S): Populus tremula 
2010-08-24 | E-GEOD-19297 | biostudies-arrayexpress
ProteomicsRobust dimethyl-based multiplex-DIA doubles single-cell proteome depth via a reference channel
Single-cell proteomics aims to characterize biological function and heterogeneity at the level of proteins in an unbiased manner. It is currently limited in proteomic depth, throughput, and robustness, which we address here by a streamlined multiplexed workflow using data-independent acquisition (mD...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-12-22 | MSV000090956 | MassIVE
ProteomicsDistinct interactomes of ADAR1 nuclear and cytoplasmic protein isoforms and their responses to Interferon induction
The RNA editing enzyme ADAR1, is essential for correct functioning of innate immune responses. The ADAR1p110 isoform is mainly nuclear and ADAR1p150, which is interferon inducible, is predominately cytoplasmic. Using three different approaches, co-IP with endogenous ADAR1, and Strep-tag co-IP and Bi...
ORGANISM(S): Homo sapiens (Human) 
2024-12-08 | PXD056080 | Pride
Rnase a Endo-ip Human Ifn response Adar A549 cells 
ProteomicsVerticillium dahliae Frq and Frh form a Frq-Frh complex in dependence on arginine 806 (R806) of Frh
The plant pathogenic fungus Verticillium dahliae has homologs of the clock genes [Cascant-Lopez et al., 2020], which are well described in Neurospora crassa [Diernfellner et al., 2020]. In N. crassa, frequency (Frq) and the Frq-interacting RNA helicase (Frh) interact and form the Frq-Frh complex [Ch...
ORGANISM(S): Verticillium dahliae JR2 
2023-07-12 | PXD041716 | Pride
Frh Clock proteins Frq-interacting rna helicase Frq Verticillium dahliae jr2 Frequency 
GenomicsFunctional analysis of AEBP2, a PRC2 Polycomb protein, reveals a Trithorax phenotype in embryonic development and in ES cells
The Polycomb repressive complexes PRC1 and PRC2 are key mediators of heritable gene silencing in multicellular organisms. Here we characterize AEBP2, a known PRC2 cofactor which, in vitro, has been shown to stimulate PRC2 activity. We show that AEBP2 localises specifically to PRC2 target loci, incl...
ORGANISM(S): Mus musculus 
2016-08-02 | E-GEOD-83082 | biostudies-arrayexpress
UnknownRobust dimethyl-based multiplex-DIA doubles single-cell proteome depth via a reference channel.
Not available
S-EPMC10495816 | biostudies-literature
ProteomicsRobust dimethyl-based multiplex-DIA doubles single-cell proteome depth via a reference channel
Single-cell proteomics aims to characterize biological function and heterogeneity at the level of proteins in an unbiased manner. It is currently limited in proteomic depth, throughput, and robustness, which we address here by a streamlined multiplexed workflow using data-independent acquisition (mD...
ORGANISM(S): Homo sapiens (Human) 
2023-08-30 | PXD038632 | Pride
Mass spectrometry Dimethyl labeling Multiplexing Dia Single cells 
TranscriptomicsInvestigation of barley brittle stem mutants
The barley brittle stem mutants, fs2, designated X054 and M245, have reduced levels of cellulose compared with their isogenic parents Ohichi and Shiroseto. A custom-designed microarray, based on Agilent technology and including genes involved in cell wall metabolism, was used to compare transcript ...
ORGANISM(S): Hordeum vulgare 
2010-07-23 | E-GEOD-17873 | biostudies-arrayexpress
ProteomicsDistinct interactomes of ADAR1 nuclear and cytoplasmic protein isoforms and their responses to Interferon induction
Adenosine deaminase acting on RNA 1 (ADAR1), is an enzyme that catalyzes the conversion of adenosine to inosine in double-stranded RNA, a process critical for regulation of innate immune response and distinguishing between ‘self and non-self RNA’. It is expressed as two isoforms: nucleolar p110 and ...
ORGANISM(S): Homo sapiens (Human) 
2024-12-08 | PXD049991 | Pride
Human Lc-ms/ms Adar Bioid Ifn 
MetabolomicsGlycolysis/gluconeogenesis specialization in microbes is driven by biochemical constraints of flux sensing
Central carbon metabolism is highly conserved across microbial species, but can catalyze very different pathways depending on the organism and their ecological niche. Here, we study the dynamic reorganization of central metabolism after switches between the two major opposing pathway configurations ...
2022-01-11 | MTBLS3887 | MetaboLights
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