Sort   by:  
 Page size 
TranscriptomicsGlobal regulation of alternative splicing by adenosine deaminase acting on RNA (ADAR) [RNA-seq]
Alternative mRNA splicing is a major mechanism for gene regulation and transcriptome diversity. Despite the extent of the phenomenon, the regulation and specificity of the splicing machinery are only partially understood. Adenosine-to-inosine (A-to-I) RNA editing of pre-mRNA by ADAR enzymes has been...
ORGANISM(S): Homo sapiens 
2013-06-17 | E-GEOD-47997 | biostudies-arrayexpress
TranscriptomicsGlobal regulation of alternative splicing by adenosine deaminase acting on RNA (ADAR) [expression]
Alternative mRNA splicing is a major mechanism for gene regulation and transcriptome diversity. Despite the extent of the phenomenon, the regulation and specificity of the splicing machinery are only partially understood. Adenosine-to-inosine (A-to-I) RNA editing of pre-mRNA by ADAR enzymes has been...
ORGANISM(S): Homo sapiens 
2013-06-15 | E-GEOD-47945 | biostudies-arrayexpress
TranscriptomicsStudy functions of ADAR proteins using next generation sequencing of genome and transcriptome
Adenosine deaminases, RNA specific (ADAR) are proteins that deaminate adenosine to inosine which is then recognized in translation as guanosine. To study the roles of ADAR proteins in RNA editing and gene regulation, we carried out DNA and RNA sequencing, RNA interference and RNA-immunoprecipitatio...
ORGANISM(S): Homo sapiens 
2013-09-20 | E-GEOD-38233 | biostudies-arrayexpress
ProteomicsStereo-random Oligonucleotides Enable Efficient Recruitment of ADAR in vitro and in vivo
We used our previously published isASO-ID protocol to identify binders for two different adenosine deaminases acting on RNA- (ADAR-) recruiting antisense oligonucleotides (ONs). The ONs differed in their phosphorothioate content and their RNA editing potency and efficiency through the recruitment of...
ORGANISM(S): Homo sapiens (Human) 
2025-07-31 | PXD066763 | Pride
Antisense oligonucleotide Basu Drug protein interactome Rna editing Proximity biotinylation Biotin ligase Silac In situ biotinylation Adar-recruiting oligonucleotides 
TranscriptomicsGlobal regulation of alternative splicing by adenosine deaminase acting on RNA (ADAR)
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2013-06-17 | E-GEOD-47998 | biostudies-arrayexpress
TranscriptomicsThe RNA editing enzyme ADAR1 is a key regulatory of innate immune responses to RNA
The ADAR RNA editing enzymes deaminate adenosine bases to inosines in cellular RNAs, recoding open reading frames. Human ADAR1 mutations cause Aicardi-Goutieres Syndrome (AGS) and Adar1 mutant mice showing an aberrant interferon response and death by embryonic day E12.5 model the human disease. Sear...
ORGANISM(S): Mus musculus 
2014-12-19 | E-GEOD-62917 | biostudies-arrayexpress
TranscriptomicsNascent-seq indicates widespread cotranscriptional RNA editing in Drosophila
The RNA editing enzyme ADAR chemically modifies adenosine (A) to inosine (I), which is interpreted by the ribosome as a guanosine. Here we assess cotranscriptional A-to-I editing in Drosophila, by isolating nascent RNA from adult fly heads and subjecting samples to high-throughput sequencing. There ...
ORGANISM(S): Drosophila melanogaster 
2012-05-31 | E-GEOD-37232 | biostudies-arrayexpress
GenomicsCytokine Stimulation of ADAR-deleted B16 murine melanoma cells
Cytokine Stimulation of ADAR-deleted B16 murine melanoma cells
PRJNA434332 | ENA
GenomicsRNAseq of hnRNPC and ADAR deficient THP-1
RNAseq of hnRNPC and ADAR deficient THP-1
PRJNA734583 | ENA
TranscriptomicsSystematic Mapping of ADAR1 Binding Reveals its Regulatory Roles in Multiple RNA Processing Pathways [small RNA-seq]
ADARs are the primary factors underlying A-to-I editing in metazoans. We conducted the first global study of ADAR1-RNA interaction in human cells using CLIP-Seq. In contrast to the expected predominant binding of ADAR1 to Alu repeats, thousands of CLIP sites were located in non-Alu regions. This une...
ORGANISM(S): Homo sapiens 
2015-03-11 | E-GEOD-55362 | biostudies-arrayexpress
Sort   by:  
 Page size