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ProteomicsHuman nucleolar RNA pol I interacting proteins identified by immuno-precipitation and mass spectrometry
Ribosome biogenesis is a highly regulated multistep process that controls cell growth and proliferation. The first and key regulatory step of ribosome biogenesis is represented by the transcription of ribosomal RNA (rRNA) genes by RNA polymerase (pol) I in the nucleolus. Activity of RNA pol I is tig...
ORGANISM(S): Homo sapiens (Human) 
2020-05-06 | PXD018143 | Pride
Human rnapoli interactors from nucleoli 
TranscriptomicsLRP8-Reelin-regulated Neuronal (LRN) Enhancer signature underlying learning and memory formation (GRO-seq)
A comprehensive landscape of epigenomic events regulated by the Reelin signaling through activation of specific cohort of cis-regulatory enhancer elements (LRN-enhancers), which involves the proteolytical processing of the LRP8 receptor by the gamma-secretase activity and is required for learning an...
ORGANISM(S): Mus musculus 
2015-04-29 | E-GEOD-66703 | biostudies-arrayexpress
TranscriptomicsTargeting MDM4/MDM2 binding interface for reactivation of p53 in cancer therapy
The aim of this experiment has been to investigate the transcriptional profile of HCT116 cells treated with Peptide-3 (Pep3) compared to untreated (NT), treated with solvent (DMSO) or with a mutated peptide (Pep3M) cells. Peptide-3 is a dodecapeptide able to interact with MDM2 at the levels of the i...
ORGANISM(S): Homo sapiens 
2017-04-18 | E-GEOD-62855 | biostudies-arrayexpress
GenomicsItalian Primary Biliary Cirrhosis Study

A Genome-wide association study of primary biliary cirrhosis (PBC) with an Italian cohort and loci meeting suggestive criteria were confirmed using a replication dataset from a previous Canadian study. The results confirmed associations for IL12A, IL12RB2, and HLA (peak between DQA1 and DQB1) and...

phs000444.v1.p1 | EGA
UnknownTemporal trends and treatment patterns in anal fissure management: insights from a multicenter study in Italy.
Not available
S-EPMC11452494 | biostudies-literature
UnknownItalian survey about intraperitoneal drain use in distal pancreatectomy.
Not available
S-EPMC11876192 | biostudies-literature
UnknownA new national survey of centers for cognitive disorders and dementias in Italy.
Not available
S-EPMC10791890 | biostudies-literature
UnknownGlobal hospital-based disease management of acute diverticulitis: a prospective, international cohort study.
Not available
S-EPMC12512976 | biostudies-literature
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