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GenomicsBromodomain inhibition of the transcriptional coactivators CBP/EP300 as a therapeutic strategy to target the IRF4 network in multiple myeloma (ChIP-Seq)
Pharmacological inhibition of chromatin co-regulatory factors represents a clinically validated strategy to modulate oncogenic signaling through selective attenuation of gene expression. Here, we demonstrate that CBP/EP300 bromodomain inhibition preferentially abrogates the viability of multiple mye...
ORGANISM(S): Homo sapiens 
2016-01-05 | E-GEOD-71909 | biostudies-arrayexpress
TranscriptomicsRegulation of GLI underlies a role for BET bromodomains in pancreatic cancer growth and the tumor microenvironment
Pancreatic ductal adenocarcinoma (PDAC) is extraordinarily chemoresistant and the abundant stromal content of these tumors contributes to the ineffective treatment of this disease. While the genetic alterations of PDAC have been well characterized, the epigenetic pathways regulating PDAC remain, fo...
ORGANISM(S): Homo sapiens 
2016-09-08 | E-GEOD-55209 | biostudies-arrayexpress
GenomicsGene expression profile at single cell level of whole lung cells from C57BL/6J mice or global STING knock-out mice (STING-/-), exposed to either room air or chronic hypoxia (4-week 10% oxygen).
Gene expression profile at single cell level of whole lung cells from C57BL/6J mice or global STING knock-out mice (STING-/-), exposed to either room air or chronic hypoxia (4-week 10% oxygen).
PRJNA1025025 | ENA
UnknownThe Effect of Botulinum Neurotoxin-A (BoNT-A) on Muscle Strength in Adult-Onset Neurological Conditions with Focal Muscle Spasticity: A Systematic Review.
Not available
S-EPMC11359732 | biostudies-literature
UnknownThe Impact of Strength Changes on Active Function Following Botulinum Neurotoxin-A (BoNT-A): A Systematic Review.
Not available
S-EPMC12390172 | biostudies-literature
UnknownRegulation of GLI Underlies a Role for BET Bromodomains in Pancreatic Cancer Growth and the Tumor Microenvironment.
Not available
S-EPMC4987213 | biostudies-literature
TranscriptomicsBromodomain inhibition of the transcriptional coactivators CBP/EP300 as a therapeutic strategy to target the IRF4 network in multiple myeloma (RNA-Seq)
Pharmacological inhibition of chromatin co-regulatory factors represents a clinically validated strategy to modulate oncogenic signaling through selective attenuation of gene expression. Here, we demonstrate that CBP/EP300 bromodomain inhibition preferentially abrogates the viability of multiple mye...
ORGANISM(S): Homo sapiens 
2016-01-05 | E-GEOD-64317 | biostudies-arrayexpress
TranscriptomicsHigh Density custom Agilent 44K CGH array analysis of 7q and TET2 region in myelodysplastic/myeloproliferative neoplasms
Abnormalities of chromosome 7q are common in myeloid malignancies. Agilent CGH arrays targeted to 7q and Affymetrix SNP 6.0 arrays were used to characterise 7q aUPD and deletions. Sample #017 in this data series showed a microdeletion encompassing EZH2. Screening of a total of 614 cases with myeloid...
ORGANISM(S): Homo sapiens 
2010-06-30 | E-GEOD-21948 | biostudies-arrayexpress
GenomicsExome sequencing in classic Hairy cell leukaemia reveals widespread variation in acquired somatic mutations between individual tumours apart from the signature BRAF V(600)E lesion
Whole exome sequencing of 5 HCLc tumor-germline pairs. Genomic DNA from HCLc tumor cells and T-cells for germline was used. Whole exome enrichment was performed with either Agilent SureSelect (50Mb, samples S3G/T, S5G/T, S9G/T) or Roche Nimblegen (44.1Mb, samples S4G/T and S6G/T). The resulting exom...
ORGANISM(S): Homo sapiens 
2016-02-01 | E-MTAB-4313 | biostudies-arrayexpress
TranscriptomicsGlobal gene expression response to BET inhibition in two cancer cell lines
The MYC transcription factor is a master regulator of diverse cancer pathways and somatic cell reprogramming. MYC is a compelling therapeutic target that exhibits cancer-specific cellular effects. Pharmacologic inhibition of MYC function has proven challenging due to its numerous modes of forced exp...
ORGANISM(S): Homo sapiens 
2011-09-18 | E-GEOD-29449 | biostudies-arrayexpress
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