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TranscriptomicsBromodomain inhibition of the transcriptional coactivators CBP/EP300 as a therapeutic strategy to target the IRF4 network in multiple myeloma
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2016-01-05 | E-GEOD-71911 | biostudies-arrayexpress
TranscriptomicsInhibitors of the histone lysine demethylase KDM1A are broadly efficacious in AML by evicting the enzyme from chromatin
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2016-02-10 | E-GEOD-71741 | biostudies-arrayexpress
GenomicsBromodomain inhibition of the transcriptional coactivators CBP/EP300 as a therapeutic strategy to target the IRF4 network in multiple myeloma (ChIP-Seq)
Pharmacological inhibition of chromatin co-regulatory factors represents a clinically validated strategy to modulate oncogenic signaling through selective attenuation of gene expression. Here, we demonstrate that CBP/EP300 bromodomain inhibition preferentially abrogates the viability of multiple mye...
ORGANISM(S): Homo sapiens 
2016-01-05 | E-GEOD-71909 | biostudies-arrayexpress
GenomicsInhibitors of the histone lysine demethylase KDM1A are broadly efficacious in AML by evicting the enzyme from chromatin [ChIP-Seq]
Examine the distribution of KDM1A and the histone H3K4me2 mark on chromatin following treatment with two distinct classes of KDM1A inhibitors - an irreversible inhibitor (RN-1) and a reversible inhibitor (GSK690) 15 samples total from two treated cell lines - 9 from Kasumi-1 and 6 from SKNO-1. Cont...
ORGANISM(S): Homo sapiens 
2016-02-10 | E-GEOD-71739 | biostudies-arrayexpress
TranscriptomicsBET bromodomain inhibition suppresses TH17-mediated pathology
IL-17-producing T helper (TH17) cells have been selected through evolution for their ability to control fungal and bacterial infections. It is also firmly established that their aberrant generation and activation results in autoimmune conditions. Using a characterized potent and selective small mole...
ORGANISM(S): Mus musculus 
2013-09-20 | E-GEOD-37270 | biostudies-arrayexpress
TranscriptomicsRegulation of GLI underlies a role for BET bromodomains in pancreatic cancer growth and the tumor microenvironment
Pancreatic ductal adenocarcinoma (PDAC) is extraordinarily chemoresistant and the abundant stromal content of these tumors contributes to the ineffective treatment of this disease. While the genetic alterations of PDAC have been well characterized, the epigenetic pathways regulating PDAC remain, fo...
ORGANISM(S): Homo sapiens 
2016-09-08 | E-GEOD-55209 | biostudies-arrayexpress
TranscriptomicsRegulatory T cell modulation by CBP/EP300 bromodomain inhibition [array]
Genome-wide gene expression changes in response to CBP inhibitor treatment in Treg cells using microarray. Expression profiling by microarray of Treg cells treated with DMSO or CBP inhibitor, and Th0 cells
ORGANISM(S): Homo sapiens 
2016-07-06 | E-GEOD-66596 | biostudies-arrayexpress
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