Sort   by:  
 Page size 
TranscriptomicsMolecular Classification and Prediction of Survival in Non-Small-Cell Lung Cancer
BACKGROUND: Global gene expression analysis provides a comprehensive molecular characterization of non-small cell lung cancer. The aim of this study was to evaluate the feasibility of integrating expression profiling into routine clinical work-up by including minute bronchoscopic biopsies and develo...
ORGANISM(S): Homo sapiens 
2008-04-10 | E-GEOD-11117 | biostudies-arrayexpress
TranscriptomicsGene expression profiles regulated by Stat5a/b vs. Stat3 in human prostate cancer cells.
Identification of the molecular changes that promote viability and metastatic behaviour of prostate cancer cells is critical for the development of improved therapeutic interventions for prostate cancer. Stat5a/b and Stat3 are both constitutively active in locally-confined and advanced prostate canc...
ORGANISM(S): Homo sapiens 
2010-05-27 | E-GEOD-17482 | biostudies-arrayexpress
TranscriptomicsAmplification and overexpression of vinculin are associated with increased tumor cell proliferation and progression in advanced prostate cancer
We analyzed the 10q22 amplification in advanced prostate cancer and subjected the genes located in the common amplified region to an RNAi screen. We found vinculin as the most promising candidate gene and analyzed its protein expression on more than 400 prostate cancers by using the tissue micrarray...
ORGANISM(S): Homo sapiens 
2011-02-08 | E-GEOD-24216 | biostudies-arrayexpress
TranscriptomicsStat5-regulated gene expression in human prostate cancer cells
Transcription factor Stat5 is constitutively active in human prostate cancer but not in normal prostate epithelium. Stat5 activation is associated with prostate cancer lesions of high histological grades, and is present in the majority of castration-resistant recurrent human prostate cancers. The mo...
ORGANISM(S): Homo sapiens 
2010-05-27 | E-GEOD-17483 | biostudies-arrayexpress
ProteomicsAn Integrated Proteomic Portrait of Prostate Cancer Progression
Cancer forms a local tumor that subsequently metastasizes to distant organs. In prostate cancer, the latter part of the trajectory is influenced by the inhibition of the androgen receptor (AR). The study of proteomic changes along disease progression may reveal insights into how prostate cancer evol...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) 
2024-10-30 | MSV000096252 | MassIVE
TranscriptomicsExon array analysis of the response to bevacizumab/erlotinib in advanced non-small cell lung cancer
In the current study, we used exon arrays and clinical samples from a previous trial (SAKK 19/05) to investigate the expression variations at the exon-level of 3 genes potentially playing a key role in modulating treatment response (EGFR, KRAS, VEGFA). Exon-level biomarkers for the response to targe...
ORGANISM(S): Homo sapiens 
2013-07-30 | E-GEOD-37138 | biostudies-arrayexpress
TranscriptomicsAdvancing a Clinically Relevant Perspective of the Clonal Nature of Cancer
We used DNA content-based flow cytometry to distinguish and isolate nuclei from clonal populations in primary tissues from three disparate cancers with variable clinical histories. We then developed a methodology to adapt flow cytometrically purified nuclei samples for use with whole genome technolo...
ORGANISM(S): Homo sapiens 
2011-07-04 | E-GEOD-21660 | biostudies-arrayexpress
TranscriptomicsDeep Clonal Profiling of Formalin-Fixed Paraffin-Embedded Clinical Samples
Formalin-fixed paraffin-embedded (FFPE) tissues are a vast resource of annotated clinical samples. As such, they represent highly desirable and informative materials for the application of high-definition genomics for improved patient management and to advance the development of personalized therape...
ORGANISM(S): Homo sapiens 
2012-12-31 | E-GEOD-40299 | biostudies-arrayexpress
Sort   by:  
 Page size