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ProteomicsLC-MSMS based Phosphoproteomics of BubR1
To identify phosphorylation sites on BubR1 that regulates its acetylation at lysine 250 (K250), LC-MSMS analysis was performed using HeLa cells expressing wild-type BubR1 (WT), an acetylation-deficient mutant (K250R), and an acetylation-mimetic mutant (K250Q).
ORGANISM(S): Homo sapiens (Human) 
2025-12-22 | PXD066850 | Pride
Bubr1 Hela Phosphorylation 
ProteomicsSelf-priming of Plk1 binding to BubR1 ensures accurate mitotic progression
Plk1 is a key mitotic kinase that localizes to distinct subcellular structures to promote accurate mitotic progression. Plk1 recruitment depends on direct interaction between polo-box domain (PBD) on Plk1 and PBD binding motif (PBD BM) on the interactors. However, recent study showed that PBD BM alo...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-10-31 | MSV000096264 | MassIVE
TranscriptomicsIncreased expression of BubR1 protects against aneuploidy in aging oocytes and extends reproductive lifespan
Chromosome aneuploidy increases in oocytes with maternal age, and is considered the leading cause for the increased incidence of infertility, miscarriage, and birth defects. Using mRNA-Sequencing of oocytes from 12 month old mouse versus 3 month young mouse, we identified a spindle assembly checkpoi...
ORGANISM(S): Mus musculus 
2014-05-10 | E-GEOD-57482 | biostudies-arrayexpress
GenomicsBubR1 Insufficiency Recapitulates Changes Associated with Age-Related Cardiac Pathologies
BubR1 Insufficiency Recapitulates Changes Associated with Age-Related Cardiac Pathologies
PRJNA1165196 | ENA
GenomicsSingle-cell whole genome sequencing of MEFs with BubR1 mutations
BubR1 allelic effects drive phenotypic heterogeneity in MVA progeria syndrom
PRJEB33810 | ENA
TranscriptomicsBubR1 Insufficiency Recapitulates Changes Associated with Age-Related Cardiac Pathologies
Aging is a major risk factor for cardiovascular diseases, including heart failure, and contributes to pathological changes such as hypertrophy, fibrosis, and cellular senescence in the heart. BubR1, a critical regulator of the spindle assembly checkpoint, has been linked to various aging phenotypes,...
ORGANISM(S): Mus musculus 
2025-09-17 | GSE277997 | GEO
GenomicsBubR1 allelic effects drive phenotypic heterogeneity in MVA progeria syndrome [3 month old RNA-seq]
BubR1 allelic effects drive phenotypic heterogeneity in MVA progeria syndrome [3 month old RNA-seq]
PRJNA556410 | ENA
GenomicsGene expression profile at single cell level of wildtype and BubR1 knockout embryonic E10.5 hearts
Gene expression profile at single cell level of wildtype and BubR1 knockout embryonic E10.5 hearts
PRJNA1125438 | ENA
Genomics
BubR1 depletion sequencing
PRJNA924253 | ENA
ProteomicsTurboID-mediated proximal labeling of Drosophila BubR1 and its cleavage variants
V5-TurboID-tagged Drosophila BubR1 and its cleavage variants were transiently expressed in Drosophila S2 cells in two biological replicates. Cells were treated with 500 µM biotin for 30 min for protein biotinylation. Biotinylated protein-containing lysate was subjected to FG-NeutrAvidin beads purifi...
ORGANISM(S): Drosophila Melanogaster (fruit Fly) 
2023-05-11 | PXD033797 | JPOST Repository
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