Sort   by:  
 Page size 
ProteomicsCrosslinking mass spectrometry of yeast Pol I pre-initiation complex
In eukaryotic cells, ribosomal RNA is transcribed by RNA polymerase I (Pol I). To initiate transcription, Pol I requires the assembly of a multi-subunit pre-initiation complex (PIC). In yeast, the minimal PIC includes Pol I, the transcription factor Rrn3 and Core Factor (CF) composed of subunits Rrn...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2017-07-31 | PXD006510 | Pride
Pol i Transcription Core factor Pol i pre-initiation complex Crosslinking Ribosomal rna 
ProteomicsSpatial tissue proteomics quantifies inter- and intra-tumor heterogeneity in hepatocellular carcinoma
The inter-patient variability of tumor proteomes has been investigated on a large scale but many tumors display also intra-tumoral heterogeneity (ITH) regarding morphological and genetic features. To what extent the local proteome of tumors intrinsically differs remains largely unknown. Here, we use...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2018-01-24 | PXD007052 | Pride
Intra-tumoral heterogeneity Liver Hepatocellular carcinoma 
ProteomicsCapturing protein communities by structural proteomics in a thermophilic eukaryote
The arrangement of proteins into complexes is a key organizational principle for many cellular functions. Although the topology of many complexes has been systematically analyzed in isolation, their molecular sociology in situ remains elusive. Here, we show that crude cellular extracts of a eukaryot...
ORGANISM(S): Chaetomium thermophilum 
2017-08-07 | PXD006660 | Pride
Xl-ms Protein communities Chaetomium thermophilum 
ProteomicsN-acetylcysteine overcomes NF1-loss driven resistance to PI3K alpha inhibition in breast cancer.
Breast cancer is the second most common cancer type worldwide, representing 25% of all cancers in women. PIK3CA is one of the most frequently mutated genes in breast cancer and mutations result in constitutive activation of the PI3K/mTOR pathway. More than 30 inhibitors against PI3K/mTOR are being t...
ORGANISM(S): Homo sapiens (Human) 
2023-03-30 | PXD034644 | Pride
Tmt Pi3k alpha inhibition Phospho proteomics Breast cancer 
ProteomicsDesign and characterization of mutated variants of the oncotoxic parvoviral protein NS1
Oncotoxic proteins such as the non-structural protein 1 (NS1), a constituent of the rodent parvovirus H1 (H1-PV), offer a novel approach for treatment of tumors that are refractory to other treatments. In the present study, mutated NS1 variants were designed and tested with respect to their oncotox...
ORGANISM(S): Homo sapiens (Human) 
2023-03-10 | PXD036350 | Pride
Np1 Tmt Lfq Hcc Parvovirus h-1 
ProteomicsShared and specific functions of Arfs 1-5 at the golgi revealed by systematic knockouts
DP-ribosylation factors (Arfs) are small GTPases regulating membrane traffic in the secretory pathway. They are closely related and appear to have overlapping functions, regulators, and effectors. The functional specificity of individual Arfs and the extent of redundancy are still largely unknow...
ORGANISM(S): Homo sapiens (Human) 
2021-11-02 | PXD028846 | Pride
Golgi Secretory pathway Copi Ap1 Arf gtpases Gga 
ProteomicsA rare-codon-based translational program of cell proliferation
The codon usage of mRNAs controls the speed of translation elongation, which is primarily determined by the abundance of cognate tRNAs. By profiling mRNA expression around the cell cycle we found that mRNAs that are relatively upregulate in the G2/M phase are enriched in rare codons. To understand ...
ORGANISM(S): Mus musculus (Mouse) 
2020-01-21 | PXD016034 | Pride
Cell proliferation Codon usage Translation elongation Rare codons Lfq Trna pools Translation control 
ProteomicsDevelopment of resistance to type II JAK2 inhibition in MPN depends on AXL kinase and is targetable
Purpose: Myeloproliferative neoplasms (MPN) dysregulate JAK2 signaling. Since clinical JAK2 inhibitors have limited disease-modifying effects, type II JAK2 inhibitors such as CHZ868 stabilizing inactive JAK2 and reducing MPN clones, gain interest. We studied whether MPN cells escape from type ll inh...
ORGANISM(S): Homo sapiens (Human) 
2023-11-07 | PXD039419 | Pride
: lfq Resistance Myeloproliferative neoplasms Mapk Chz868 Axl Phosphoproteomics Dda Jak2 inhibition 
ProteomicsLongitudinal evaluation of biomarkers in wound fluids of venous leg ulcers treated with a protease-modulating wound dressing
Venous leg ulcers (VLU) represent a clinical challenge and impair the patient’s quality of life. Venous insufficiency is underlying the protracted healing. We report the protein expression pattern for biomarkers in VLU wound fluids and compare these with acute split-thickness wound fluids. Fifty-se...
ORGANISM(S): Homo Sapiens 
2023-08-22 | PXD025748 | panorama
Sort   by:  
 Page size