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The hormone prolactin is implicated in the pathogenesis of breast cancer, and a subset of prolactin-induced gene expression is mediated by HDAC6 activity. The NSAID, bufexamac, is a fairly specific inhibitor of HDAC6 and HDAC10. We used bufexamac in combination with prolactin treatment in MCF7 cells...
ORGANISM(S): Homo sapiens 
2016-05-07 | GSE81217 | GEO
Transcriptome analysis of activated CD4+ T cells treated either with sodium butyrate or bufexamac
Sodium butyrate and bufexamac treatment of activated CD4+ T cells impairs de novo HIV-1 infection. RNAseq was used to obtain information about the cellular changes upon treatment, which could explain the observed effects on HIV-1 infection
ORGANISM(S): Homo sapiens 
2021-03-11 | GSE146854 | GEO
Gene expression data from MCF7 breast adenocarcinoma cells treated with prolactin and/or bufexamac
Lysine deacetylases (KDACs) are important regulators of biological processes. KDAC inhibitors (KDACIs) are important tools for basic research and attractive therapeutic candidates, yet their effects on in-vivo acetylation sites are poorly known. Here we obtained acetylation signatures for 19 differe...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2015-02-16 | PXD001377 | Pride
Data from ProteomeXchange: PXD ID: PXD001377. Experiment: Bufexamacproteome_hs_LH, file: 20120521_QE3_LC2_CHS_SA_Bufexamacproteome_03.mzml. From ProteomeXchange: {{i}} Lysine deacetylases (KDACs) are important regulators of biological processes. KDAC inhibitors (KDACIs) are important tools for basic...
ORGANISM(S): Homo_sapiens_viruses, Human 
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