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Evaluation of genetic inactivation of lysine deacetylases KDAC6 (HDAC6) and KDAC8 (HDAC8) versus treatment with KDAC-selective inhibitors
To investigate the specificity and biological impacts of KDAC-selective inhibitors, we treated wild-type HT1080 cells and cell lines containing point mutations that result in endogenous expression of a catalytically-inactive variant with KDAC6 and KDAC8 selective inhibitors Tubastatin A and PCI-3405...
ORGANISM(S): Homo sapiens 
2024-02-15 | GSE251743 | GEO
To investigate the specificity and biological impacts of KDAC-selective inhibitors, we treated wild-type HT1080 cells with KDAC6 selective inhibitors SW-113 and SE-138. Expression profiling analysis was then performed on the treated cells vs. untreated wild-type HT1080 cells. Comparable wild-type da...
ORGANISM(S): Homo sapiens 
2026-07-01 | GSE302384 | GEO
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