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TranscriptomicsMultiorgan effects of IUGR caused by maternal protein depletion in rats (Placenta, Kidney, Heart, Lung, Liver)
All genome expression changes investigated on pools of growth restricted rats (at term) compared to control rats. The protocol of growth restriction (length, duration) has been extensively described in Buffat et al (Journal of Pathology 2007a and Endocrinology, 2007b) Ten hybridizations, two technic...
ORGANISM(S): Rattus norvegicus 
2011-12-23 | E-GEOD-25764 | biostudies-arrayexpress
TranscriptomicsExpression of brain gene at P4 and P10 post-coïtus in the rat, after protein restriction of the mother regimen during gestation
Total brain was collected from newborn rats that were growth-restricted obtained by feeding the females a low-protein diet during pregnancy. The model was extensively described in Buffat et al, J. Pathology 2007, and Zana-Taieb et al, J. Pathology, 2015.
ORGANISM(S): Rattus norvegicus 
2016-10-14 | E-MTAB-4646 | biostudies-arrayexpress
TranscriptomicsSeparated transcriptome analysis of microglial cells and oligodendrocytes in the brain of P4 rats, in intra-uterine growth restriction or control conditions
Females were exposed during pregnancy to a normal or low protein diet (as described in Buffat et al, J. Pathol, 2007 and Zana-Taieb et al, J. Pathol, 2015). Brains cells were dissociated using the Neural Tissue Dissociation Kit of Miltenyi Biotec,in the presence of papain. Then Magnetic Bead couple...
ORGANISM(S): Rattus norvegicus 
2016-10-14 | E-MTAB-4647 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat heart, kidney and placenta from fetuses obtained from dams with diet-induced intra-uterine growth restriction vs. normal
Pregnant rats were randomly divided into two groups. Dams were then housed individually and fed throughout gestation a 22 % protein diet, representing the control group (C, n=5), or an 9% isocaloric protein diet, representing the low-protein (LP, n=6). Both diets were isocaloric, because the protei...
ORGANISM(S): Rattus norvegicus 
2007-11-03 | E-MEXP-1015 | biostudies-arrayexpress
TranscriptomicsRegulatory role of multinucleated giant cells derived from placental CD14+ macrophages: Pathophysiological implications
The role of placental macrophages is largely ignored in the success of pregnancy. We found that CD14+ macrophages purified from at-term placentas spontaneously matured into multinucleated giant cells (MGCs). MGCs lost the expression of CD14 and co-inhibitory molecules, such as Programmed cell Death-...
ORGANISM(S): Homo sapiens 
2014-01-07 | E-GEOD-38747 | biostudies-arrayexpress
UnknownIntegrated transcriptome analysis of the cellular mechanisms associated with Ha-ras-dependent malignant transformation of the human breast epithelial MCF7 cell line.
Not available
S-EPMC206462 | biostudies-literature
UnknownLow-dose aspirin protective effects are correlated with deregulation of HNF factor expression in the preeclamptic placentas from mice and humans.
Not available
S-EPMC6510804 | biostudies-literature
UnknownRetinoic acid receptor subtype-specific transcriptotypes in the early zebrafish embryo.
Not available
S-EPMC5427955 | biostudies-literature
UnknownAn Automated Recording Method in Clinical Consultation to Rate the Limp in Lower Limb Osteoarthritis.
Not available
S-EPMC5077168 | biostudies-literature
UnknownThe intensity of IUGR-induced transcriptome deregulations is inversely correlated with the onset of organ function in a rat model.
Not available
S-EPMC3120850 | biostudies-literature
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