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UnknownRisk variants and polygenic architecture of disruptive behavior disorders in the context of attention-deficit/hyperactivity disorder.
Attention-Deficit/Hyperactivity Disorder (ADHD) is a childhood psychiatric disorder often comorbid with disruptive behavior disorders (DBDs). Here, we report a GWAS meta-analysis of ADHD comorbid with DBDs (ADHD + DBDs) including 3802 cases and 31,305 controls. We identify three genome-wide signific...
S-EPMC7835232 | biostudies-literature
UnknownDiscovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder.
Attention deficit/hyperactivity disorder (ADHD) is a highly heritable childhood behavioral disorder affecting 5% of children and 2.5% of adults. Common genetic variants contribute substantially to ADHD susceptibility, but no variants have been robustly associated with ADHD. We report a genome-wide a...
S-EPMC6481311 | biostudies-literature
UnknownGreater male than female variability in regional brain structure across the lifespan.
For many traits, males show greater variability than females, with possible implications for understanding sex differences in health and disease. Here, the ENIGMA (Enhancing Neuro Imaging Genetics through Meta-Analysis) Consortium presents the largest-ever mega-analysis of sex differences in variabi...
S-EPMC8675415 | biostudies-literature
UnknownSubcortical volumes across the lifespan: Data from 18,605 healthy individuals aged 3-90 years.
Age has a major effect on brain volume. However, the normative studies available are constrained by small sample sizes, restricted age coverage and significant methodological variability. These limitations introduce inconsistencies and may obscure or distort the lifespan trajectories of brain morpho...
S-EPMC8675429 | biostudies-literature
UnknownCortical thickness across the lifespan: Data from 17,075 healthy individuals aged 3-90 years.
Delineating the association of age and cortical thickness in healthy individuals is critical given the association of cortical thickness with cognition and behavior. Previous research has shown that robust estimates of the association between age and brain morphometry require large-scale studies. In...
S-EPMC8675431 | biostudies-literature
UnknownVirtual Histology of Cortical Thickness and Shared Neurobiology in 6 Psychiatric Disorders.

Importance

Large-scale neuroimaging studies have revealed group differences in cortical thickness across many psychiatric disorders. The underlying neurobiology behind these differences is not well understood.

Objective

To determine neurobiologic correlates of group differences in cor...
S-EPMC7450410 | biostudies-literature
UnknownNovel genetic loci associated with hippocampal volume.
The hippocampal formation is a brain structure integrally involved in episodic memory, spatial navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal volume and shape are found in several common neuropsychiatric disorders. To identify the genetic underpinnings of hi...
S-EPMC5253632 | biostudies-literature
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