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TranscriptomicsCoexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells
CD4(+) type 1 T regulatory (Tr1) cells are induced in the periphery and have a pivotal role in promoting and maintaining tolerance. The absence of surface markers that uniquely identify Tr1 cells has limited their study and clinical applications. By gene expression profiling of human Tr1 cell clones...
ORGANISM(S): Homo sapiens 
2013-12-20 | E-GEOD-53514 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse functionally distinct radial glial subsets
Since the discovery of radial glia as the source of neurons, their heterogeneity in regard to neurogenesis has been described by clonal and time-lapse analysis in vitro. However, the molecular determinants specifying neurogenic radial glia differently from radial glia that mostly self-renew remain i...
ORGANISM(S): Mus musculus 
2008-06-18 | E-GEOD-8034 | biostudies-arrayexpress
TranscriptomicsLentiviral vector-based insertional mutagenesis identifies new clinically relevant cancer genes involved in the pathogenesis of hepatocellular carcinoma
We devised a novel insertional mutagenesis approach based on lentiviral vectors to induce hepatocellular carcinoma in three mouse models and identified four novel cancer initiating genes. Two genes are the well characterized Braf and Sos1, while the other two are Fign, encoding an AAA ATPase whose f...
ORGANISM(S): Mus musculus 
2012-12-20 | E-GEOD-31409 | biostudies-arrayexpress
TranscriptomicsLentiviral vector-based insertional mutagenesis identifies new clinically relevant candidate cancer genes involved in the pathogenesis of hepatocellular carcinoma
We devised a novel insertional mutagenesis approach based on lentiviral vectors to induce hepatocellular carcinoma in three mouse models and identified four novel cancer initiating genes. Two genes are the well characterized Braf and Sos1, while the other two are Fign, encoding an AAA ATPase whose f...
ORGANISM(S): Homo sapiens 
2015-02-19 | E-GEOD-35986 | biostudies-arrayexpress
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