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GenomicsGenome-wide binding profiles of an artificial zinc finger protein with or without a KLF3 functional domain
Transcription factors are often regarded as having two distinct components: a DNA binding domain (DBD) to allow binding to the regulatory region of a target gene and a trans-acting functional domain (FD) to modulate gene expression. Recently, it is becoming clear that the DBDs of transcription facto...
ORGANISM(S): Homo sapiens 
2016-01-05 | E-GEOD-69739 | biostudies-arrayexpress
TranscriptomicsRNA-Seq analysis of KLF3 knockout E14.5 TER119+ (erythroid) murine fetal liver cells
The aim of this study was to analyze the transcriptome of TER119+ fetal liver cells in the absence of the transcription factor KLF3 at murine embryonic day E14.5 Three wildtype (WT; Klf3+/+) and three knockout (KO; Klf3-/-) samples
ORGANISM(S): Mus musculus 
2014-02-23 | E-GEOD-50554 | biostudies-arrayexpress
GenomicsGenome-wide binding profiles of KLF3 and KLF3 mutants in MEF cells
Transcription factors are often regarded as being comprised of a DNA-binding domain and a functional domain. The two domains are considered separable and autonomous, with the DNA-binding domain directing the factor to its target genes and the functional domain imparting transcriptional regulation. W...
ORGANISM(S): Mus musculus 
2013-10-17 | E-GEOD-44748 | biostudies-arrayexpress
TranscriptomicsKrüppel-like factor 3 KO and rescue expression data in murine embyronic fibroblasts
Krüppel-like factor 3 (KLF3) is a transcriptional repressor that has roles in adipogenesis, B-cell maturation and erythropoiesis (for review see Pearson et al., 2012). We profiled gene expression in murine embryonic fibroblasts (MEFs) where Klf3 had been knocked-out and where the same cell had been ...
ORGANISM(S): Mus musculus 
2013-10-17 | E-GEOD-44744 | biostudies-arrayexpress
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