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TranscriptomicsRole of ICOS:ICOSL interaction in acute GVHD
Inducible co-stimulator (ICOS) interaction with its ligand (ICOSL) is involved in several T cell effector functions. While blockade of ICOS:ICOSL interaction in chronic graft versus host disease (GVHD) seems benefi cial, results for acute GVHD remain controversial. To further elucidate its role in a...
ORGANISM(S): Mus musculus 
2009-09-14 | E-GEOD-17995 | biostudies-arrayexpress
GenomicsGenome-wide binding profiles of an artificial zinc finger protein with or without a KLF3 functional domain
Transcription factors are often regarded as having two distinct components: a DNA binding domain (DBD) to allow binding to the regulatory region of a target gene and a trans-acting functional domain (FD) to modulate gene expression. Recently, it is becoming clear that the DBDs of transcription facto...
ORGANISM(S): Homo sapiens 
2016-01-05 | E-GEOD-69739 | biostudies-arrayexpress
TranscriptomicsEpigenetic Maintenance of Stemness and Malignancy in Peripheral Neuroectodermal Tumors by EZH2
Chromatin modifications are increasingly recognized as a key mechanism in cancer. The histone methyl-transferase Enhancer of Zeste, Drosophila, Homolog 2 (EZH2) is the enzymatic subunit of the polycomb PRC2 complex and methylates histone H3K27, thereby, mediating gene silencing. Down-regulation of E...
ORGANISM(S): Homo sapiens 
2010-05-18 | E-GEOD-15890 | biostudies-arrayexpress
TranscriptomicsPRC2 in Ewing tumors
We found the PRC2 component EZH2 to be upregulated by the pathognomonic fusion oncogene EWS-FLI1 in Ewing tumors and mesenchymal stem cells (Richter GH et al., Proc Natl Acad Sci U S A. 2009;106:5324-9). Downregulation of EZH2 by RNA interference in Ewing tumor cell lines suppressed oncogenic transf...
ORGANISM(S): Homo sapiens 
2009-04-29 | E-GEOD-15757 | biostudies-arrayexpress
TranscriptomicsRNA-Seq analysis of KLF3 knockout E14.5 TER119+ (erythroid) murine fetal liver cells
The aim of this study was to analyze the transcriptome of TER119+ fetal liver cells in the absence of the transcription factor KLF3 at murine embryonic day E14.5 Three wildtype (WT; Klf3+/+) and three knockout (KO; Klf3-/-) samples
ORGANISM(S): Mus musculus 
2014-02-23 | E-GEOD-50554 | biostudies-arrayexpress
TranscriptomicsTargeting the EWS/ETS transcriptional program by BET bromodomain inhibition in Ewing sarcoma
Ewing sarcomas (ES) are highly malignant, osteolytic bone or soft tissue tumors, which are characterized by early metastasis into lung and bone. Genetically, ES are defined by balanced chromosomal EWS/ETS translocations, which give rise to chimeric proteins (EWS-ETS) that generate an oncogenic trans...
ORGANISM(S): Homo sapiens 
2015-12-08 | E-GEOD-72673 | biostudies-arrayexpress
TranscriptomicsGene expression in pediatric cALL
Common ALL (cALL) is the most frequent entity of childhood ALL and carries an early pre-B cell phenotype. Expression patterns of 25 pediatric cALL samples were analyzed by use of high-density DNA microarrays HG-U133A. Leukemic patients’ bone marrow samples were compared to sorted B cells from cord...
ORGANISM(S): Homo sapiens 
2012-06-29 | E-GEOD-34670 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of Hodgkin’s lymphoma cell lines with different sensitivity to cytotoxic drugs
By using high-density DNA microarrays, we analyzed the gene-expression profile of Hodgkin's lymphoma cell lines. Furthermore, we tested the sensitivity of these cell lines for cytotoxic drugs (cisplatin, etoposide, melphalan) and compared the gene-expression profile of chemotherapy-resistant and -se...
ORGANISM(S): Homo sapiens 
2011-01-10 | E-GEOD-26325 | biostudies-arrayexpress
TranscriptomicsKrüppel-like factor 3 KO and rescue expression data in murine embyronic fibroblasts
Krüppel-like factor 3 (KLF3) is a transcriptional repressor that has roles in adipogenesis, B-cell maturation and erythropoiesis (for review see Pearson et al., 2012). We profiled gene expression in murine embryonic fibroblasts (MEFs) where Klf3 had been knocked-out and where the same cell had been ...
ORGANISM(S): Mus musculus 
2013-10-17 | E-GEOD-44744 | biostudies-arrayexpress
UnknownProspective evaluation of multitarget treatment of pediatric patients with helical intensity-modulated radiotherapy.
Not available
S-EPMC7686189 | biostudies-literature
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