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TranscriptomicsTranscription profiling by array of human dendritic cells after Poly(I:C)-based or PGE2-based maturation
Generation of human monocyte-derived DCs Peripheral blood mononuclear cells (PBMC) were isolated by Ficoll density centrifugation from buffy coats or whole blood of healthy donors and resuspended in serum-free medium (CellGro, CellGenix GmbH, Freiburg, Germany), supplemented with penicillin (50U/ml)...
ORGANISM(S): Homo sapiens 
2008-11-01 | E-MEXP-1230 | biostudies-arrayexpress
TranscriptomicsTranscriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP: IGF2BP data
To test the influence of IGF2BPs on the stability of their interacting mRNAs, as reported previously for some targets (Yisraeli, 2005), we simultaneously depleted all three IGF2BP family members using siRNAs and compared the cellular RNA from knockdown and mock-transfected cells on microarrays. The ...
ORGANISM(S): Homo sapiens 
2010-05-27 | E-GEOD-21575 | biostudies-arrayexpress
UnknownProtection of CD33-modified hematopoietic stem cell progeny from CD33-directed CAR T cells in rhesus macaques.
Not available
S-EPMC12141896 | biostudies-literature
TranscriptomicsTranscriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP: QKI data
To assess whether the transcripts identified by PAR-CLIP are regulated by the RNA-binding protein (RBP) Quaking (QKI), we analyzed the mRNA levels of mock-transfected and QKI-specific siRNA-transfected cells with microarrays. Transcripts crosslinked to QKI were significantly upregulated upon siRNA t...
ORGANISM(S): Homo sapiens 
2010-05-27 | E-GEOD-21574 | biostudies-arrayexpress
TranscriptomicsTranscriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP: miRNA inhibition data
To obtain evidence that Argonaute (AGO) crosslink-centered regions (CCRs) indeed contain functional miRNA-binding sites, we blocked 25 of the most abundant miRNAs in HEK 293 cells (Figure 5C of PMID 20371350) by transfection of a cocktail of 2'-O-methyl-modified antisense oligoribonucleotides and mo...
ORGANISM(S): Homo sapiens 
2010-05-27 | E-GEOD-21577 | biostudies-arrayexpress
UnknownInduction chemotherapy and conformal radiation therapy for very young children with nonmetastatic medulloblastoma: Children's Oncology Group study P9934.
Not available
S-EPMC3434977 | biostudies-literature
MetabolomicsProMetIS, deep phenotyping of mouse models by combined proteomics and metabolomics analysis

Genes are pleiotropic and getting a better knowledge of their function requires a comprehensive characterization of their mutants. Here, we generated multi-level data combining phenomic, proteomic and metabolomic acquisitions from plasma and liver tissues of two C57BL/6 N mouse models lacking the...

2021-09-01 | MTBLS1903 | MetaboLights
ProteomicsA druggable redox switch on SHP1 controls macrophage inflammation
Immunological proteins are major disease targets and the majority remain undrugged. Post-translational redox modification of protein cysteine residues has emerged as a mode of immune cell regulation, especially in the context of the macrophage cytokine response.1 Here, we develop a strategy for syst...
ORGANISM(S): Homo sapiens (Human) 
2026-02-24 | PXD055006 | Pride
Shp-1  hdx-ms  hydrogen/deuterium exchange mass spectrometry  covalent activator 
UnknownThe Bruchpilot cytomatrix determines the size of the readily releasable pool of synaptic vesicles.
Not available
S-EPMC3747298 | biostudies-literature
ProteomicsBurger_et_al_ilicicolin_metabolomics
In this study, the ilicicolin biosynthetic gene cluster (BGC) in Trichoderma reesei was genetically activated, and a series of gene cluster enzyme deletions were performed. Mycelia were harvested and subjected to polar extraction. The resulting polar extracts were analyzed using an untargeted lipido...
ORGANISM(S): Trichoderma Reesei (ncbitaxon:51453) 
MSV000095813 | MassIVE
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