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GenomicsStreptomyces sp. SHP 1-2
Streptomyces sp. SHP 1-2 Genome sequencing and assembly
PRJNA661228 | ENA
TranscriptomicsExpression data of hepatic iNKT cells from pLck-hCD1d transgenic mice
CD1d expression by thymocytes is required to select iNKT cells. When CD1d is expressed only on thymocytes (pLck-CD1d tg mice), iNKT cells are hyperresponsive to antigen stimulation suggesting that, in physiological conditions, these cells undergo functional education mediated by additional CD1d-expr...
ORGANISM(S): Mus musculus 
2013-03-01 | E-GEOD-42835 | biostudies-arrayexpress
ProteomicsSHP-1(FLAG) AP-MS, with/without TAOK3 and/or SRC kinase
To understand the influence of phosphorylation on the protein-protein interactions, we performed an AP-MS of SHP-1(FLAG) in HEK293T/17 cells co-transfected with TAOK3 and/or SRC kinase. Whilst TAOK3 phosphorylates Thr-394, SRC phosphorylates Tyr536 and Tyr564.
ORGANISM(S): Homo sapiens (Human) 
2024-01-04 | PXD042497 | Pride
Ap-ms Shp-1(flag) Ppis Taok3 Phosphorylation Src 
TranscriptomicsTCR affinity-dependent functional inhibition via PD-1 and SHP-1 phosphatase
To investigate gene expression changes associated with stimulation of TCRs of different affinity, primary CD8 T cells were transduced with sequence optimized TCRs of various affinities and stimulated for 6h. Gene expression was measured at baseline (0h) and after 6h after stimulation with low dose N...
ORGANISM(S): Homo sapiens 
2013-02-11 | E-GEOD-42922 | biostudies-arrayexpress
ProteomicsConcomitant deletion of Shp-1 and Shp-2 in T cells fails to improve anticancer responses 
Anticancer T cells acquire a dysfunctional state characterized by poor effector function and expression of inhibitory receptors, such as programmed cell death protein 1 (PD-1). Blockade of PD-1 signalling leads to T cell reinvigoration and is increasingly applied as an effective anticancer treatment...
ORGANISM(S): Mus musculus (Mouse) 
2022-09-29 | PXD034897 | Pride
Shp-2  shp-1  ptpn11  ptpn6  t cell exhaustion  cancer immunotherapy  inhibitory receptors  pd-1 checkpoint therapy  
GenomicsSHP-1 regulates transcription of PCK1 to control gluconeogenesis
SHP-1 regulates transcription of PCK1 to control gluconeogenesis
PRJNA728582 | ENA
TranscriptomicsSHP-1 dependent dephosphorylation of Histone H2B acts as a molecular switch to facilitate transcription
1.Comparison of chromatin occupancy of H2BUb and RNA Polymerase II in SHP-1 WT and KO MCF7 cells. Paired end sequencing (2X100 bp) was performed on the Illumina HiSeq X ten. 2.Identification of the SHP-1 binding site in MCF7 cells using ChIP Seq. Paired end sequencing (2X100 bp) was performed on the...
ORGANISM(S): Homo sapiens 
2022-06-01 | E-MTAB-10295 | biostudies-arrayexpress
GenomicsSHP-1 regulates transcription of PCK1 to control gluconeogenesis
The protein-tyrosine phosphatase SHP-1 (PTPN6) is an important glucose homeostasis modulator. Besides negatively regulating insulin signaling, the specific role of SHP-1 in metabolic control remains poorly understood. We show that SHP-1 acts as a co-activator for transcription of the phosphoenolpyru...
ORGANISM(S): Homo sapiens 
2023-09-08 | GSE174142 | GEO
TranscriptomicsscRNA-seq of tumor infiltrating CD11c + cells in ItgaxΔPtpn6 model
This study investigates the role of dendritic cells (DCs) in anti-tumor immunity, focusing on the phosphatase SHP-1 and its regulation of signaling pathways and interactions with CD8+ T cells. Using conditional knockout mouse models and single-cell transcriptomics, we show that SHP-1 loss in convent...
ORGANISM(S): Mus musculus 
2026-04-15 | E-MTAB-16912 | biostudies-arrayexpress
GenomicsSHP-1 dependent dephosphorylation of Histone H2B acts as a molecular switch to facilitate transcription
SHP-1 dependent dephosphorylation of Histone H2B acts as a molecular switch to facilitate transcription
PRJEB44066 | ENA
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