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ProteomicsMultiple regulatory intrinsically disordered motifs control FOXO4 transcription factor binding and function
Transcription factors harbour defined intrinsically disordered regulatory regions, which raises the question of how they mediate binding to structured co-regulators and how this regulates activity. Here, we present a detailed molecular regulatory mechanism of Forkhead box O4 (FOXO4) by the structure...
ORGANISM(S): Homo sapiens (Human) 
2022-04-15 | PXD026263 | Pride
Foxo signalling Post-translational modification Icat Structural biology Intrinsically disordered proteins Nmr spectroscopy Transcription factors Wnt signalling -catenin Phosphorylation 
ProteomicsHsa-miR-31-5p controls a metabolic switch in psoriatic keratinocytes that identifies therapeutic intervention
Next to genetic alterations, it is being recognized that the cellular environment also acts as a major determinant in onset and progression of disease. In cases where different cell types contribute to the final disease outcome, this imposes environmental challenges as different cell types likely di...
ORGANISM(S): Homo sapiens (Human) 
2023-02-06 | PXD029030 | Pride
Mir-31metabolism psoriasis keratinocytes 
TranscriptomicsTranscription profiling of human DLD-1 cells stably expressing FOXO3a.A3-ER
In order to elucidate how FOXOs affect diverse cellular processes such as cell cycle progression, stress response and transformation we made use of an inducible version of the FOXO3a protein fused to the hormone binding domain of the human estrogen receptor (FOXO3a-A3-ER) in which all three Akt phos...
ORGANISM(S): Homo sapiens 
2007-03-01 | E-MEXP-721 | biostudies-arrayexpress
MetabolomicsLactate controls cancer stemness and plasticity through epigenetic regulation.

Tumours arise from uncontrolled cell proliferation driven by mutations in genes that regulate stem cell renewal and differentiation. Intestinal tumours, however, retain some hierarchical organization, maintaining both cancer stem cells (CSCs) and cancer differentiated cells (CDCs). This heterogen...

2025-05-28 | MTBLS11849 | MetaboLights
OtherEvolutionary Acquisition of Cysteines determines FOXO Paralog-Specific Redox Signaling
Data from ProteomeXchange, PXD ID: PXD001018. Experiment: HRV_A, file: folder summary. Published as part of Antioxid Redox Signal. 2014 Jul 29 . From the Abstract: {{i}} Reduction-oxidation (redox) signaling, the translation of an oxidative intracellular environment into a cellular response, is med...
ORGANISM(S): Homo_sapiens_viruses, Human 
GPM32320002469 | GPMDB
Resource Reanalysis 
GenomicsGenome wide analysis of FOXO3 transcription regulation through RNA pol II profiling
FOXO transcription factors are key players in diverse cellular processes affecting tumorigenesis, stem cell maintenance and lifespan. To gain insight into mechanisms of FOXO regulated target gene expression, we studied genome-wide effects of FOXO3 activation. Profiling RNA polymerase II changes show...
ORGANISM(S): Homo sapiens 
2012-11-15 | E-GEOD-35486 | biostudies-arrayexpress
GenomicsFOXO3 regulates gene expression from distal enhancers
FOXO transcription factors are key players in diverse cellular responses affecting tumorigenesis, stem cell maintenance and lifespan. To gain insight into mechanisms of FOXO regulated gene expression, we studied genome-wide effects of FOXO3 activation. Profiling RNA polymerase II (RNAPII) changes sh...
ORGANISM(S): Homo sapiens 
2012-12-30 | E-GEOD-36835 | biostudies-arrayexpress
TranscriptomicsCP003: Modulation of glutamine metabolism by the PI3K-PKB/c-akt-FOXO network regulates autophagy
The PI3K-PKB/c-akt-FOXO signalling network provides a major intracellular hub for regulation of cell proliferation, survival and stress resistance1. Here we report a novel function for FOXO transcription factors in regulating autophagy through modulation of intracellular glutamine levels. To identif...
ORGANISM(S): Mus musculus 
2012-07-21 | E-GEOD-35703 | biostudies-arrayexpress
TranscriptomicsCP001: Modulation of glutamine metabolism by the PI3K-PKB/c-akt-FOXO network regulates autophagy
The PI3K-PKB/c-akt-FOXO signalling network provides a major intracellular hub for regulation of cell proliferation, survival and stress resistance1. Here we report a novel function for FOXO transcription factors in regulating autophagy through modulation of intracellular glutamine levels. To identif...
ORGANISM(S): Mus musculus 
2012-07-21 | E-GEOD-35701 | biostudies-arrayexpress
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