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MetabolomicsUntargeted Metabolomics Reveals a Lack Of Synergy between Nifurtimox and Eflornithine against Trypanosoma brucei
A non-targeted metabolomics-based approach is presented that enables the study of pathways in response to drug action with the aim of defining the mode of action of trypanocides. Eflornithine, a polyamine pathway inhibitor, and nifurtimox, whose mode of action involves its metabolic activation, are ...
2017-06-07 | MTBLS459 | MetaboLights
GenomicsEscherichia coli
flagellar regulon studies
PRJNA97205 | ENA
GenomicsEscherichia coli
sigma32 over-expression in E. coli
PRJNA91269 | ENA
ProteomicsA pipeline that integrates the discovery and verification of plasma protein biomarkers reveals candidate markers for cardiovascular disease
Addona TA, Shi X, Keshishian H, Mani DR, Burgess M, Gillette MA, Clauser KR, Shen D, Lewis GD, Farrell LA, Fifer MA, Sabatine MS, Gerszten RE, Carr SA. Nat Biotechnol. 2011, 29(7):635-43. doi: 10.1038/nbt.1899. PMCID:PMC3366591. Discovery, AIMS, and MRM datasets Discovery_Tranche_hash: b/quYtp/Q8fY...
2013-12-19 | MSV000078513 | MassIVE
TranscriptomicsTranscription profiling of E.coli overexpressing sigma32
This study examined the genes under the control of sigma32 in E. coli by moderate induction of a plasmid-borne rpoH gene under defined steady-state growth condition. Samples were taken from culture at mid log phase (OD=0.2) before or 5 minutes, 10 minutes or 15 minutes after induction. Samples were ...
ORGANISM(S): Escherichia coli 
2008-06-11 | E-GEOD-2140 | biostudies-arrayexpress
UnknownAssociations of genetically predicted IL-6 signaling with cardiovascular disease risk across population subgroups.
Not available
S-EPMC9367072 | biostudies-literature
ProteomicsA Nanobody inhibitor of Fascin-1 actin-bundling activity and filopodia formation
Fascin-1 mediated actin-bundling activity is central to the generation of plasma membrane protrusions required for cell migration. Dysregulation of cellular protrusions is observed in metastatic cancers, where they are required for increased invasiveness, and this is often correlated with overexpres...
ORGANISM(S): Homo sapiens (Human) 
2024-03-25 | PXD038713 | Pride
Fascin-1 Hydrogen deuterium exchange Nanobody Hdx 
Transcriptomics16s RNA sequencing data from environmental and steel corrosion samples, Shoreham Harbour, UK
16s RNA gene sequencing data from seawater, bed sediment and steel corrosion samples from Shoreham Harbour, UK, collected to allow bacterial species comparisons between microbially influenced corrosion, the surrounding seawater, and the sea bed sediment at the seafloor and 50cm depth below seafloor.
ORGANISM(S): metagenome 
2019-10-06 | E-MTAB-8373 | biostudies-arrayexpress
MetabolomicsAmphotericin B resistance in Leishmania mexicana: Alterations to sterol metabolism, lipid transport and oxidative stress response

Amphotericin B is increasingly used in treatment of leishmaniasis. Here, fourteen independent lines of Leishmania mexicana and one L. infantum line were selected for resistance to either amphotericin B or the related polyene antimicrobial, nystatin. Sterol profiling revealed tha...

2022-09-22 | MTBLS2744 | MetaboLights
UnknownEpidermal growth factor potentiates EGFR(Y992/1173)-mediated therapeutic response of triple negative breast cancer cells to cold atmospheric plasma-activated medium.
Not available
S-EPMC10746566 | biostudies-literature
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