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TranscriptomicsThe relationship between DNA methylation, genetic and expression inter-individual variation in untransformed human fibroblasts
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2013-12-13 | E-GEOD-53261 | biostudies-arrayexpress
TranscriptomicsRNA-seq of Actinosynnema mirum grown in GYM medium compared to growth in TB medium.
Actinosynnema mirum cells were grown in 3 biological replicates and harvested in exponential growth phase either grown in terrific broth (TB) or in glucose-yeast-malt (GYM) medium to analyse the differential gene expression under different grwoth media. A preculture of A. mirum was grown in 20 mL NL...
ORGANISM(S): Actinosynnema mirum DSM 43827 
2021-02-25 | E-MTAB-10100 | biostudies-arrayexpress
TranscriptomicsIntegration of high-resolution methylome and transcriptome analyses to dissect epigenomic changes in childhood acute lymphoblastic leukemia
B-cell precursor acute lymphoblastic leukemia (pre-B ALL) is the most common pediatric cancer. Although the genetic origin of the disease remains unclear, epigenetic modifications including DNA methylation are suggested to contribute significantly to leukemogenesis. We assessed the DNA methylation s...
ORGANISM(S): Homo sapiens 
2013-06-04 | E-GEOD-38235 | biostudies-arrayexpress
GenomicsThe relationship between DNA methylation, genetic and expression inter-individual variation in untransformed human fibroblasts [Whole genome bisulfite sequencing]
Background DNA methylation has long been known to play an essential role in the epigenetic regulation of gene expression and other cellular functions, and has been in some cases linked to genetic variation. While its presence near the transcription start site of a gene has been associated with reduc...
ORGANISM(S): Homo sapiens 
2014-01-25 | E-GEOD-54373 | biostudies-arrayexpress
TranscriptomicsThe relationship between DNA methylation, genetic and expression inter-individual variation in untransformed human fibroblasts [expression profiling]
Background: DNA methylation has long been known to play an essential role in the epigenetic regulation of gene expression and other cellular functions, and has been in some cases linked to genetic variation. While its presence near the transcription start site of a gene has been associated with red...
ORGANISM(S): Homo sapiens 
2013-12-13 | E-GEOD-53243 | biostudies-arrayexpress
TranscriptomicsThe relationship between DNA methylation, genetic and expression inter-individual variation in untransformed human fibroblasts [methylation profiling]
Background DNA methylation has long been known to play an essential role in the epigenetic regulation of gene expression and other cellular functions, and has been in some cases linked to genetic variation. While its presence near the transcription start site of a gene has been associated with red...
ORGANISM(S): Homo sapiens 
2013-12-10 | E-GEOD-52025 | biostudies-arrayexpress
TranscriptomicsMethylation profiling by array of subcutaneous fat derived from 856 TwinsUK participants
Epigenetic changes such as DNA methylation variation are known to play a role in gene regulation and common disease susceptibility. Little is known about the genome-wide frequency, localization and function of such changes and how they are regulated by genetic and environmental factors. We have util...
ORGANISM(S): Homo sapiens 
2013-10-01 | E-MTAB-1866 | biostudies-arrayexpress
GenomicsPopulation whole-genome bisulfite sequencing across two tissues highlights environment as principal source of human methylome variation
The study includes whole-genome bisulfite sequencing (WGBS) on 34 adipose (7 MZ pairs, 6 DZ pairs and 8 singletons) and 27 blood (7 MZ pairs, 6 DZ pairs and 1 singleton) DNA samples derived from a total of 43 female twins belonging to the MuTHER/TwinsUK cohort. We generated 11.5 billion 100bp paired...
EGAS00001001569 | EGA
GenomicsMCGILL_R4.H3K9ME3 - samples
McGill EMC Release 4 for assay "H3K9me3"
EGAD00001001299 | EGA
GenomicsMCGILL_R4.VENOUS_BLOOD.CD4-POSITIVE_HELPER_T_CELL - samples
McGill EMC Release 4 in tissue "venous blood" for cell type "CD4-positive helper T cell"
EGAD00001001279 | EGA
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