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TranscriptomicsRNAseq of Staphylococcus aureus wildtype and ppGpp0 mutant reveals rolen of alarmon (p)ppGpp confering tolerance to oxidative stress and antibiotics during the stationary phase in Staphylococcus aureus
RNAseq of coding RNA in Staphylococcus aureus wildtype and ppGpp0 mutant shows transcription of the Fe-storage ferritin (ftnA) and miniferritin (dps) was elevated in the ppGpp0 mutant, while Fur-regulated iron transporters for uptake of heme or siderophores were repressed, including the isdABCDEFG, ...
ORGANISM(S): Staphylococcus aureus subsp. aureus USA300 
2020-08-31 | E-MTAB-9368 | biostudies-arrayexpress
TranscriptomicsRNA-seq of coding RNA of Actinoplanes sp. SE50/110 to analyze gene function of alternative sigma factor gene ACSP50_0507
Cultivation in maltose minimal media and sampling at different time point (t2 = 96h; t3=118h; t4 = 142h; t5 = 166h) of Actinoplanes sp. SE50/110 empty vector control and Actinoplanes sp. SE50/110 ACSP50_0507 overxepression mutant. RNAseq material and methods
ORGANISM(S): Actinoplanes sp. SE50/110 
2024-07-22 | E-MTAB-13644 | biostudies-arrayexpress
ProteomicsExoproteome analysis of Staphylococcus aureus clinical isolates belonging to different clonal complexes (C22, CC8 and CC398)
Studies on S. aureus sub-populations revealed that genomes are well conserved between isolates from the same lineages despite geographic, temporal and selective diversity. However, variation of hundreds of genes can occur between isolates from different lineages and these genes could be involved in ...
ORGANISM(S): Staphylococcus aureus 
2018-09-11 | PXD008797 | Pride
Clonal complex Exoproteome Virulence factors Staphylococcus aureus Secretome 
ProteomicsThe garlic compound allicin causes strong disulfide stress and protein S-sulfoallylation as revealed by proteomics and transcriptomics in Staphylococcus aureus
Allicin from garlic is an antimicrobial substance that is effective against several ESKAPE pathogens, including methicillin-resistant Staphylococcus aureus (MRSA). However, the antimicrobial mode action of allicin has not been revealed in Gram-positive bacteria. Here, we have studied the changes in ...
ORGANISM(S): Staphylococcus aureus 
2022-02-28 | PXD010338 | Pride
Proteomics Allicin stress Transcriptomics Staphylococcus aureus S-sulfoallylation 
TranscriptomicsRNA-seq system comparison of Streptomyces lividans TK24 cultivated under micro-scale biolector and reference bioreactor conditions
The comprehensive transcriptome of Streptomyces lividans TK24 in a biolector milliliter-scale cultivation system was compared in detail against an established 1000-fold larger lab-scale bioreactor system. For main-cultures, the modified minimal medium NMMP (D'Huys et al. 2011) was applied, containi...
ORGANISM(S): Streptomyces lividans 
2016-08-31 | E-MTAB-5047 | biostudies-arrayexpress
TranscriptomicsDetermination of the transcription start sites of heterologous promoters in Actinoplanes sp. SE50/110 by 5'-end specific transcriptome sequencing
The promoter structure influences binding and clearance of RNA polymerase and therefore substantially influences expression of a gene. A promoter usually consists of a -10 and a -35-region, an extended -10-motif and A+T-rich upstream promoter elements. Most of these elements are optional, whereas th...
ORGANISM(S): Actinoplanes sp. SE50/110 
2019-10-26 | E-MTAB-8433 | biostudies-arrayexpress
TranscriptomicsDeciphering the transcriptional response mediated by the redox-sensing system HbpS-SenS-SenR from streptomycetes
Comparative analyses of the transcriptomes of the Streptomyces coelicolor A3(2) wild-type and the generated hbpSc-senSc-senRc (hsr) mutant under native and oxidative-stressing conditions allowed to identify differentially expressed genes, whose products may enhance the anti-oxidative defense of the ...
ORGANISM(S): Streptomyces coelicolor 
2016-06-30 | E-MTAB-4833 | biostudies-arrayexpress
TranscriptomicsRNA-seq of Streptomyces coelicolor and Streptomyces davawensis including a dodecin gene deletion variant in response to plumbagin treatment
Genes encoding dodecin proteins are present in almost 20% of archaeal and in more than 50% of bacterial genomes. Archaeal dodecins bind riboflavin (vitamin B2), are thought to play a role in flavin homeostasis and possibly also help to protect cells from radical or oxygenic stress. Bacterial dodecin...
ORGANISM(S): Streptomyces coelicolor A3(2) 
2018-04-07 | E-MTAB-6633 | biostudies-arrayexpress
TranscriptomicsComplex response on the level of the transcriptome by deletion of a local transcriptional repressor AmlR by RNAseq of the coding RNA
Actinoplanes sp. SE50/110 is the wild type of industrial production strains of the fine-chemical acarbose (acarviosyl-maltose), which is used as α-glucosidase inhibitor in the treatment of type II diabetes. Although maltose is an important building block of acarbose, the maltose/maltodextrin metabol...
ORGANISM(S): Actinoplanes sp. SE50/110 
2019-10-07 | E-MTAB-8404 | biostudies-arrayexpress
TranscriptomicsTranscriptional analysis of regulatory effects in Corynebacterium glutamicum and a derived (p)ppGpp0 mutant strain
The alarmone species ppGpp and pppGpp are an important part of bacterial physiology as they both coordinate the bacterial stress response to nutrient deficiency and also contribute to the maintenance of cell homeostasis. Recently, all components of the (p)ppGpp metabolism for the industrially releva...
ORGANISM(S): Corynebacterium glutamicum ATCC 13032 
2019-12-02 | E-MTAB-8070 | biostudies-arrayexpress
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