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TranscriptomicsMethionine Sulfoximine Resistance in Mycobacterium tuberculosis Is Due to a Single Nucleotide Deletion Resulting in Increased Expression of the Major Glutamine Synthetase, GlnA1.
We investigated the effect of methionine sulfoximine (MetSox), a potent inhibitor of glutamine synthetase, on Mycobacterium tuberculosis. M. tuberculosis encodes four glutamine synthetases, of which MetSox targets the type I enzyme encoded by glnA1. Trancriptional profiling revealed that glutamate s...
ORGANISM(S): Mycobacterium tuberculosis 
2011-09-06 | E-BUGS-112 | biostudies-arrayexpress
UnknownMycobacterium tuberculosis expresses a novel pH-dependent divalent cation transporter belonging to the Nramp family.
Not available
S-EPMC2195619 | biostudies-literature
TranscriptomicsMicroarray analysis of defined Mycobacterium tuberculosis populations using RNA amplification strategies
Background The amplification of bacterial RNA is required if complex host-pathogen interactions are to be studied where the recovery of bacterial RNA is limited. Here, using a whole genome Mycobacterium tuberculosis microarray to measure cross-genome representation of amplified mRNA populations, we ...
ORGANISM(S): Mycobacterium tuberculosis 
2008-03-12 | E-BUGS-42 | biostudies-arrayexpress
UnknownWhole-genome sequencing suggests mechanisms for 22q11.2 deletion-associated Parkinson's disease.
Not available
S-EPMC5400231 | biostudies-literature
TranscriptomicsDissection of the heat-shock response in Mycobacterium tuberculosis using mutants and microarrays
Regulation of the expression of heat-shock proteins plays an important role in the pathogenesis of Mycobacterium tuberculosis. The heat-shock response of bacteria involves genome-wide changes in gene expression. A combination of targeted mutagenesis and whole-genome expression profiling was used to ...
ORGANISM(S): Mycobacterium tuberculosis 
2007-03-07 | E-BUGS-2 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by tiling array of Potassium availability triggers Mycobacterium tuberculosis transition to, and resuscitation from, non-culturable (dormant) states
Dormancy in non-sporulating bacteria is an interesting and underexplored phenomenon with significant medical implications. In particular, latent tuberculosis may result from the maintenance of Mycobacterium tuberculosis bacilli in non-replicating states in infected individuals. Uniquely, growth of M...
ORGANISM(S): Mycobacterium tuberculosis 
2015-02-25 | E-BUGS-151 | biostudies-arrayexpress
TranscriptomicsComparative genomic hybridization of Beijing and non-Beijing Myocobacterium tuberculosis isolates from Myanmar
Background. The Beijing family of Mycobacterium tuberculosis is dominant in countries in East Asia. Genomic polymorphisms are a source of diversity within the M.tuberculosis genome and may account for the variation of virulence among M.tuberculosis isolates. To date there are no studies that have ex...
ORGANISM(S): Mycobacterium tuberculosis 
2008-09-26 | E-BUGS-66 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Mycobacterium tuberculosis grown in vitro and obtained from sputum to investigate the effect of whether they contain lipid bodies
Data is also available from http://bugs.sgul.ac.uk/E-BUGS-52
ORGANISM(S): Mycobacterium tuberculosis 
2008-04-02 | E-BUGS-52 | biostudies-arrayexpress
UnknownTrisomy 21 dysregulates T cell lineages toward an autoimmunity-prone state associated with interferon hyperactivity.
Not available
S-EPMC6883781 | biostudies-literature
UnknownDissection of ESAT-6 system 1 of Mycobacterium tuberculosis and impact on immunogenicity and virulence.
Not available
S-EPMC1346617 | biostudies-literature
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