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ProteomicsFibrinogen function achieved through multiple covalent states
Disulfide bonds link pairs of cysteine amino acids and their formation is assumed to be complete in the mature, functional protein. We tested this assumption by quantifying the redox state of disulfide bonds in the thrombosis protein, fibrinogen. There is an extraordinary disulfide lability in fibri...
ORGANISM(S): Homo sapiens (Human) 
2020-11-09 | PXD018564 | Pride
Redox state Fibrinogen Cysteines Alpha2 macroglobulin 
ProteomicsMechano‐covalent protection 1 of procoagulant factor VIII by von Willebrand factor
von Willebrand factor (VWF) is the protective carrier of procoagulant factor VIII (FVIII) in the shear forces of the circulation, prolonging its half‐life and delivering it to the developing thrombus. VWF∙FVIII complex formation is characterized by catch‐bond behavior in which force first decelerat...
ORGANISM(S): Homo sapiens (Human) 
2023-07-20 | PXD034866 | Pride
Cysteines Factor fviii Von willebrand factor Disulphide bonds 
ProteomicsPatient anti-FVIII drug antibodies bind preferentially to a subset of FVIII covalent states
Haemophilia A is a chronic life-threatening condition caused by deficiency or dysfunction of plasma coagulation factor VIII (FVIII) and prophylaxis by regular infusion of FVIII protein is a common treatment. A major obstacle to FVIII replacement therapy is the generation of alloantibodies that dimin...
ORGANISM(S): Homo sapiens (Human) 
2025-08-04 | PXD060297 | Pride
Plasma Mass spec Fviii 
UnknownbNAber: database of broadly neutralizing HIV antibodies.
Not available
S-EPMC3964981 | biostudies-literature
UnknownPreconception Cardiometabolic Markers and Birth Outcomes Among Women in the Hispanic Community Health Study/Study of Latinos.
Not available
S-EPMC9805846 | biostudies-literature
UnknownDemographic and sociocultural risk factors for adulthood weight gain in Hispanic/Latinos: results from the Hispanic Community Health Study / Study of Latinos (HCHS/SOL).
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S-EPMC8582171 | biostudies-literature
UnknownSociodemographic, Clinical, and Psychosocial Predictors of Short- and Long-term Study Retention in the Diabetes Prevention Program (DPP) Outcomes Study (DPPOS).
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S-EPMC12451849 | biostudies-literature
UnknownComparative Effects of Glucose-Lowering Medications on Kidney Outcomes in Type 2 Diabetes: The GRADE Randomized Clinical Trial.
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S-EPMC10203973 | biostudies-literature
UnknownElicitation of Robust Tier 2 Neutralizing Antibody Responses in Nonhuman Primates by HIV Envelope Trimer Immunization Using Optimized Approaches.
Not available
S-EPMC5483234 | biostudies-literature
UnknownDifferences in Prevalence and Incidence of Electrocardiogram Abnormalities and Cardiovascular Autonomic Neuropathy Among Randomized Glucose-Lowering Treatments in Early Type 2 Diabetes: The Glycemia Reduction Approaches in Diabetes (GRADE) Cohort.
Not available
S-EPMC12583396 | biostudies-literature
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