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ProteomicsPatient anti-FVIII drug antibodies bind preferentially to a subset of FVIII covalent states
Haemophilia A is a chronic life-threatening condition caused by deficiency or dysfunction of plasma coagulation factor VIII (FVIII) and prophylaxis by regular infusion of FVIII protein is a common treatment. A major obstacle to FVIII replacement therapy is the generation of alloantibodies that dimin...
ORGANISM(S): Homo sapiens (Human) 
2025-08-04 | PXD060297 | Pride
Plasma Mass spec Fviii 
ProteomicsMHC class II presentation of FVIII-AnnexinA5 fusion proteins internalized by antigen presenting cells
The development of neutralizing antibodies (inhibitors) against coagulation factor VIII (FVIII) remains the most serious complication in the treatment of hemophilia A. While immune tolerance induction (ITI) is the standard strategy to eliminate these antibodies, it fails in approximately 30% of pati...
ORGANISM(S): Homo sapiens (Human) 
2025-10-20 | PXD068424 | Pride
Annexin a5 Phosphatidylserine Immune response Fviii Antigen presentation 
ProteomicsFVIII peptides presented on HLA-DP and identification of an A3 domain peptide binding with high affinity to the commonly expressed HLA-DP4
The development of neutralizing antibodies (inhibitors) against coagulation factor VIII (FVIII) poses a major challenge in hemophilia A (HA) treatment. The formation of FVIII inhibitors is a CD4+ T-cell-dependent mechanism which includes anti- gen presenting cells (APC), B- and T-helper lymphocytes....
ORGANISM(S): Homo sapiens (Human) 
2025-10-03 | PXD069096 | Pride
Hemophilia a Inhibitors Immunity Factor viii 
ProteomicsExploring red blood cells as an antigen delivery system to modulate the immune response towards FVIII in hemophilia A
Background: The main complication in hemophilia A treatment is the development of inhibitory antibodies against factor (F)VIII. Immune tolerance induction, the gold standard for eradicating anti-FVIII antibodies, is efficient in only 60% to 80% of cases. This underscores the need for more efficient in...
ORGANISM(S): Homo sapiens (Human) 
2025-10-02 | PXD069058 | Pride
Hemophilia a Erythrocytes Inhibitors Immunity Factor viii 
GenomicsGABARAPs proteins modulate FVIII secretion in molecule-specific manner via energy related pathways
GABARAPs proteins modulate FVIII secretion in molecule-specific manner via energy related pathways
PRJNA1120569 | ENA
TranscriptomicsGABARAPs proteins modulate FVIII secretion in molecule-specific manner via energy related pathways
Little is known about the biogenesis of Factor VIII (FVIII), its control of expression, intracellular trafficking, secretion, and associated cellular energy requirements. In this project, we employed a Y2H approach in to identify new interacting proteins that may play a role in the above mentioned p...
ORGANISM(S): Homo sapiens 
2026-06-30 | GSE269206 | GEO
Genomics
Variant FVIII
PRJNA1258303 | ENA
TranscriptomicsThe self-reactive FVIII T cell repertoire in healthy individuals relies on a short set of epitopes and public clonotypes
Non-mutated FVIII-specific CD4 T cell epitopes have been recently found to contribute to the development of inhibitors in patients with hemophilia A (HA), while auto-reactive CD4 T cells specific to FVIII circulate in the blood of healthy individuals at a frequency close to the foreign protein Ovalb...
ORGANISM(S): Homo sapiens 
2024-01-22 | GSE253521 | GEO
ProteomicsTolerogenic dendritic cells generated in vitro using a novel protocol mimicking mucosal tolerance mechanisms represent a potential therapeutic cell platform for induction of immune tolerance
Dendritic cells (DCs) are mediators between innate and adaptive immunity and Q8 vital in initiating and modulating antigen-specific immune responses. The most important site for induction of tolerance is the gut mucosa, where TGF-b, retinoic acid, and aryl hydrocarbon receptors collaborate in DCs to...
ORGANISM(S): Homo sapiens (Human) 
2023-10-11 | PXD045810 | Pride
Tolerogenic dendritic cells (toldcs) Regulatory b cells (bregs) Regulatory t cells (tregs) Cell therapy Antigen-specific response Antigen loading Immune tolerance 
GenomicsThe self-reactive FVIII T cell repertoire in healthy individuals relies on a short set of epitopes and public clonotypes
The self-reactive FVIII T cell repertoire in healthy individuals relies on a short set of epitopes and public clonotypes
PRJNA1066202 | ENA
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