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UnknownFeasibility and acceptability of the TEAM pilot trial with African American and Latino families.
Not available
S-EPMC12225676 | biostudies-literature
TranscriptomicsTranscription profiling of rat chronic exposure to cigarette smoke
Chronic obstructive pulmonary disease is a smoking-related disease that lacks effective therapies due partly to the poor understanding of disease pathogenesis. The aim of this study was to identify molecular pathways which could be responsible for the damaging consequences of smoking. To do this, w...
ORGANISM(S): Rattus norvegicus 
2008-06-15 | E-GEOD-7079 | biostudies-arrayexpress
TranscriptomicsVisceral Endoderm differentiation mediated by Hnf1B and is required for epiblast survival
E5.0 entails an intermediate state for primitive endoderm (PE) to visceral endoderm (VE) differentiation: a process required for proper embryonic development. Hnf1b is essential for primitive to visceral endoderm differentiation from E4.5 to E5.5. To understand development at E5.0 and pinpoint the r...
ORGANISM(S): Mus musculus 
2024-11-19 | E-MTAB-11140 | biostudies-arrayexpress
ProteomicsGel LC-MS/MS analyses of MMP cleavage of tryptophanyl-tRNA synthetase
Tryptophanyl-tRNA synthetase was incubated by MMPs, cleavage products were resolved on SDS-PAGE. Cleavage products were trypsin digested and analyzed by LC-MS/MS.
ORGANISM(S): Homo sapiens (Human) 
2019-05-29 | PXD013217 | Pride
Mmp Protease Lc-ms/ms 
TranscriptomicsHigh resolution analysis of genomic imprinting in the embryonic and adult mouse brain AND Sex-specific imprinting in the mouse brain
Genomic imprinting results in the preferential expression of the paternal, or maternal allele of certain genes. We have performed a genome-wide characterization of imprinting in the mouse embryonic and adult brain using F1 hybrid mice generated from reciprocal crosses of CASTEiJ and C57BL/6J mice. ...
ORGANISM(S): Mus musculus 
2010-07-08 | E-GEOD-22131 | biostudies-arrayexpress
ProteomicsLC-MS/MS analyses of MMP cleavage fragments of tyrosyl-tRNA synthetase
Tyrosyl-tRNA synthetase was digested with MMPs after which cleavage fragments were resolved using SDS-PAGE. Major bands were digested with trypsin and analyzed by LC-MS/MS.
ORGANISM(S): Homo sapiens (Human) 
2019-05-30 | PXD013197 | Pride
Mmp Protease Lc-ms/ms 
GenomicsOrigins and functional consequence of somatic mitochondrial DNA mutations
Recent sequencing studies have extensively explored the somatic alterations present in the nuclear genomes of cancers. Although mitochondria control energy metabolism and apoptosis, the origins and impact of cancer-associated mutations in mitochondrial DNA (mtDNA) are unclear. Here, we analysed soma...
EGAS00001000968 | EGA
ProteomicsSARS_CoV-2 substrate profiling in HEK-293 cell proteomes
To profile the human substrate degradome of the SARS-CoV-2 main viral protease by exposingnative proteome extracts from human embryonic kidney (HEK-293) cells (N = 3) to 3CLpro cleavage. Then, N Terminal Amine Labeling of Substates (TAILS) was used to identify the substrates. Here, heavy [+34] isoto...
ORGANISM(S): Homo sapiens (Human) 
2021-11-03 | PXD026797 | Pride
Bruker q-tof Sars-cov-2 Covid19 Tails-n-terminomics 3clpro Nsp5 
ProteomicsSARS_CoV-2 substrate profiling in interferon-treated BEAS-2B cell proteomes
To profile the human substrate degradome of the SARS-CoV-2 main viral protease and to investigate whether 3CLpro cleavage of cellular substrates dampens host antiviral responses induced by type I interferons, we treated BEAS-2B cells with interferon-alpha (N = 3), interferon-beta (N = 3), or vehicle...
ORGANISM(S): Homo sapiens (Human) 
2021-11-03 | PXD026815 | Pride
Bruker q-tof Sars-cov-2 3clpro Interferon Byonic Lung Tails 
ProteomicsTAILS proteomics of murine pancreatic tumors
Aberrant proteolysis by cysteine cathepsins is implicated in carcinogenesis, but knowledge of cathepsin substrates mediating tumor-promoting or suppressing effects is limited. Here we characterize tumor proteome and in vivo cathepsin substrates using cathepsin knockout mice and the RIP1-Tag2 model o...
ORGANISM(S): Mus musculus (Mouse) 
2016-08-08 | PXD003637 | Pride
Pancreatic neuroendocrine cancer Ecm Proteomics Substrate discovery Proteolytic processing Degradation Proteases Tails n-terminomics Cysteine cathepsins 
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