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ProteomicsProteomic profiling maps the molecular pathways underlying the neuroprotective effects of the kinase inhibitor BX795 in a patient-derived model of Parkinson's disease
Disease-modifying therapies remain an important unmet need for neurodegenerative diseases, including Parkinson’s disease (PD). The aim of this study was to investigate the molecular pathways affected by the multi-kinase inhibitor BX795, which is neuroprotective in an induced pluripotent stem cell (i...
ORGANISM(S): Homo sapiens (Human) 
2023-03-10 | PXD019574 | Pride
Proteomics Mrna metabolism Induced pluripotent stem cell derived neurons Bx795 P.a53t α-synuclein mutation Proteostasis Α-synuclein 
UnknownBX795-Organic Acid Coevaporates: Evaluation of Solid-State Characteristics, In Vitro Cytocompatibility and In Vitro Activity against HSV-1 and HSV-2.
Not available
S-EPMC8623185 | biostudies-literature
GenomicsBX795 small inhibitor of TBK1 effect on mouse fibroblast cell line that transfected with pEGFP-N1 plasmid
BX795 small inhibitor of TBK1 effect on mouse fibroblast cell line that transfected with pEGFP-N1 plasmid
PRJNA605326 | ENA
UnknownAn off-target effect of BX795 blocks herpes simplex virus type 1 infection of the eye.
Not available
S-EPMC7540910 | biostudies-literature
UnknownIn Vitro and In Vivo Activity, Tolerability, and Mechanism of Action of BX795 as an Antiviral against Herpes Simplex Virus 2 Genital Infection.
Not available
S-EPMC7449169 | biostudies-literature
UnknownProphylactic treatment with BX795 blocks activation of AKT and its downstream targets to protect vaginal keratinocytes and vaginal epithelium from HSV-2 infection.
Not available
S-EPMC8446323 | biostudies-literature
TranscriptomicsBX795 small inhibitor of TBK1 effect on mouse fibroblast cell line that transfected with pEGFP-N1 plasmid
Abstract：DNA transfection is widely used in biomedical research. However, transfection efficiency is often the bottleneck of research and gene therapy practices. To explore the mechanism regulating transgene expression, we investigated the possible involvement of the cGAS-STING signaling pathway, wh...
ORGANISM(S): Mus musculus 
2020-04-03 | GSE144913 | GEO
UnknownUse of the pharmacological inhibitor BX795 to study the regulation and physiological roles of TBK1 and IkappaB kinase epsilon: a distinct upstream kinase mediates Ser-172 phosphorylation and activation.
Not available
S-EPMC2682862 | biostudies-literature
UnknownEnhancing the Efficacy of CAR-T Cell Production Using BX795 and Rosuvastatin in a Serum-Free Medium.
Not available
S-EPMC11988885 | biostudies-literature
UnknownPDK1 Inhibitor BX795 Improves Cisplatin and Radio-Efficacy in Oral Squamous Cell Carcinoma by Downregulating the PDK1/CD47/Akt-Mediated Glycolysis Signaling Pathway.
Not available
S-EPMC8584253 | biostudies-literature
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