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TranscriptomicsGenetic Screen Identifies MicroRNA Cluster 99b/let-7e/125a as a Regulator of Primitive Hematopoietic Cells
This SuperSeries is composed of the following subset Series: GSE33689: Expression profiles of HSPCs overexpressing microRNA cluster 99b/let-7e/125a, miR-125a, miR-155 and empty vector. GSE33690: MicroRNA profiles of four developmentally related hematopoietic cell types isolated from the BM of B6 and...
ORGANISM(S): Mus musculus 
2011-12-15 | E-GEOD-33691 | biostudies-arrayexpress
TranscriptomicsmRNA profiles of four developmentally related hematopoietic cell types (LSK, L-S-K+, Gr1+ and Ter119+) isolated from the BM of B6 and D2 mice
The combination of valproic acid and lithium delays hematopoietic stem\progenitor differentiation Microarray-based microRNA profiling study was peformed of four developmentally related hematopoietic cell types isolated from the BM of B6 and D2 mice. Total RNA isolated from purified LSK multilineage ...
ORGANISM(S): Mus musculus 
2012-01-25 | E-GEOD-35292 | biostudies-arrayexpress
GenomicsPolycomb Cbx orthologs mediate the balance between Hematopoietic Stem Cell self-renewal and differentiation
By genome-wide ChIP-seq analyses we show that Cbx7 and Cbx8 share ~95% of their targets in bone marrow cells. Cbx7 and Cbx8 have only ~200 targets that are not overlapping between the two proteins. These distinct Cbx7 and Cbx8 targets show reciprocal expression patterns along hematopoietic different...
ORGANISM(S): Mus musculus 
2012-12-21 | E-GEOD-36658 | biostudies-arrayexpress
TranscriptomicsSca-1 is an early-response target of histone deacetylase inhibitors and marks hematopoietic cells with enhanced function
Expression profiles of LSK cells stimulated for 24h in the presence or in the absence of of valproic acid (VPA) The molecular process that underlies the biological effects of valproic acid (VPA), a widely used histone deacetylase inhibitor, on HSPCs was investigated by studying the early-response ge...
ORGANISM(S): Mus musculus 
2012-09-25 | E-GEOD-41020 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse quantitative trait loci (QTLs) in uantitative trait loci (QTLs) and brain to identify genes and loci that control hematopoietic stem cell (HSC) functioning
We have combined large-scale mRNA expression and gene mapping methods to identify genes and loci that control hematopoietic stem cell (HSC) functioning. mRNA expression levels were measured in purified HSC isolated from a panel of densely genotyped recombinant inbred mouse strains. Quantitative trai...
ORGANISM(S): Mus musculus 
2007-11-16 | E-GEOD-2031 | biostudies-arrayexpress
TranscriptomicsExpression profiles of HSPCs overexpressing microRNA cluster 99b/let-7e/125a, miR-125a, miR-155 and empty vector.
Hematopoietic stem/progenitor cell (HSPC) traits differ between genetically distinct mouse strains. For example, DBA/2 mice have a higher HSPC frequency compared to C57BL/6 mice. We performed a genetic screen for microRNAs that are differentially expressed between LSK, LS−K+, erythroid and myeloid c...
ORGANISM(S): Mus musculus 
2011-12-15 | E-GEOD-33689 | biostudies-arrayexpress
TranscriptomicsExpression profiles of 7-day cultured HSPCs in the presence or absence of valproic acid and/or lithium
Two small molecules, valproic acid (VPA) and lithium (Li), were tested to inhibit differentiation of hematopoietic stem/progenitor (HSPC) cells in culture. HSPCs exposed to VPA and Li during differentiation-inducing culture preserved an immature cell phenotype, provided radioprotection to lethally i...
ORGANISM(S): Mus musculus 
2012-01-24 | E-GEOD-35291 | biostudies-arrayexpress
TranscriptomicsThe combination of valproic acid and lithium prevents hematopoietic stem/progenitor cell differentiation.
Expression profiles of 7-day cultured HSPCs in the presence or absence of valproic acid and/or lithium. Two small molecules, valproic acid (VPA) and lithium (Li), were tested to inhibit differentiation of hematopoietic stem/progenitor (HSPC) cells in culture. HSPCs exposed to VPA and Li during diffe...
ORGANISM(S): Mus musculus 
2011-12-15 | E-GEOD-34088 | biostudies-arrayexpress
TranscriptomicsMicroRNA profiles of four developmentally related hematopoietic cell types isolated from the BM of B6 and D2 mice.
performed a genetic screen for microRNAs that are differentially expressed between LSK, LS−K+, erythroid and myeloid cells isolated from C57BL/6 and DBA/2 mice. This analysis identified 131 microRNAs that were differentially expressed between cell types and 15 that were differentially expressed betw...
ORGANISM(S): Mus musculus 
2011-12-15 | E-GEOD-33690 | biostudies-arrayexpress
TranscriptomicsLeukemia dynamics and heterogeneity traced by barcoding in a pre-clinical Cbx7 mouse model
Gene expression analysis of different leukemia types after overexpression of Cbx7 in mice hematopoietic stem and progenitor cells followed by transplantation. Mice developed three different types of leukemia, 1) erythroid, 2) T-cell, 3) undifferentiated, as shown in K.Klauke et al. Nat Cell Biol 201...
ORGANISM(S): Mus musculus 
2014-10-01 | E-GEOD-56820 | biostudies-arrayexpress
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