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MetabolomicsThe Sphingolipidome of the model organism Caenorhabditis elegans
Sphingolipids are important lipids and integral members of membranes, where they form small microdomains called lipid rafts. These rafts are enriched in cholesterol and sphingolipids, which influences biophysical properties. Interestingly, the membranes of the biomedical model organism Caenorhabditi...
2024-04-01 | MTBLS963 | MetaboLights
MetabolomicsSteady state isotope tracing in C. elegans (GC-MS analyses)

The metabolic network, composed of thousands of metabolic reactions, is essential for any organism. Despite its importance, a systems level understanding of how metabolic network is wired by reactions that carry flux in unperturbed condition and rewired by transcriptionally activating or repressi...

2024-12-03 | MTBLS11742 | MetaboLights
MetabolomicsSteady state isotope tracing in C. elegans (LC-MS analyses)

The metabolic network, composed of thousands of metabolic reactions, is essential for any organism. Despite its importance, a systems level understanding of how metabolic network is wired by reactions that carry flux in unperturbed condition and rewired by transcriptionally activating or repressi...

2024-12-03 | MTBLS11741 | MetaboLights
MetabolomicsPolyketide synthase-derived sphingolipids determine microbiota-mediated protection against pathogens in C. elegans

Protection against pathogens is a major function of the gut microbiota. Although bacterial natural products have emerged as crucial components of host-microbiota interactions, their exact role in microbiota-mediated protection is largely unexplored. We addressed this knowledge gap with the nemato...

2025-05-27 | MTBLS8440 | MetaboLights
MetabolomicsUntargeted metabolomics analysis of Caenorhabditis elegans
The effects of probiotics on metabolites in Caenorhabditis elegans
2026-07-20 | MTBLS15105 | MetaboLights
MetabolomicsGut metabolome of Trachemys scripta elegans after fecal microbiota transplantation and supplement GABA,Arg in feed.

Extract the intestinal contents of Trachemys scripta elegans subjected to environmental stress at a salinity of ten PSU for 6 months, isolate the gut microbiota, and transplant them into other healthy Trachemys scripta elegans to observe their gut microbiota metabolite. Add GAGA and Arg to the fe...

2025-07-09 | MTBLS12187 | MetaboLights
MetabolomicsTargeted Metabolome of Caenorhabditis elegans

The effect of Lactiplantibacillus plantarum Q7 on SCFAs in Caenorhabditis elegans

2026-07-20 | MTBLS14034 | MetaboLights
MetabolomicsTargeting phospholipase PLAG-15 promotes healthy aging in C. elegans via lysosomal-related genes
Complex lipid metabolism plays a crucial role in regulating aging. We recently discovered that the phospholipid bis(monoacylglycero)phosphate (BMP) increases in aged human muscles and many mouse tissues. The phospholipase PLA2G15 is reportedly involved in BMP synthesis, however, its specific role in...
2025-06-19 | MTBLS12324 | MetaboLights
MetabolomicsPhosphoglycolate phosphatase homologs act as glycerol-3-phosphate phosphatase to control stress and healthspan in C. elegans
Metabolic stress due to nutrient excess and lipid accumulation is at the root of many age-associated disorders and the identification of therapeutic targets that mimic the beneficial effects of calorie restriction has clinical importance. Here, using C. elegans as a model organism, we study the role...
2021-09-28 | MTBLS3485 | MetaboLights
MetabolomicsA metabolomic strategy defines the regulation of lipid content and global metabolism by Δ9 desaturases in Caenorhabditis elegans
Caenorhabditis elegans provides a genetically tractable model organism to investigate the network of genes involved in fat metabolism and how regulation is perturbed to produce the complex phenotype of obesity. C. elegans possess the full range of desaturases, including the delta-9 desaturases expre...
2012-02-14 | MTBLS3 | MetaboLights
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