C-sh2 domain - OmicsDI

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418 [Affymetrix] (3)
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2010 (333)
2013 (303)
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2018 (42)
2004 (39)
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2019 (33)
2017 (33)
2003 (6)
2002 (2)

CHEBI ID

CHEBI:6650 (5)
CHEBI:18237 (4)
CHEBI:15741 (4)
CHEBI:30769 (4)
CHEBI:16113 (3)
CHEBI:17822 (3)
CHEBI:15428 (3)
CHEBI:16958 (3)
CHEBI:28044 (3)
CHEBI:18257 (3)
CHEBI:16335 (3)
CHEBI:18012 (3)
CHEBI:30915 (3)
CHEBI:28623 (2)
CHEBI:16857 (2)
CHEBI:16000 (2)
CHEBI:42111 (2)
CHEBI:16865 (2)
CHEBI:17154 (2)
CHEBI:15356 (2)
CHEBI:22653 (2)
CHEBI:16449 (2)
CHEBI:27266 (2)
CHEBI:16811 (2)
CHEBI:30772 (2)
CHEBI:16856 (2)
CHEBI:16040 (2)
CHEBI:25017 (2)
CHEBI:17053 (2)
CHEBI:17858 (2)

Metabolite Name

Succinic acid (4)
Lactic acid (3)
Fumaric acid (3)
Citric acid (3)
Glutamic acid (3)
Thymidine (3)
Inosine (3)
Hypoxanthine (3)
3-Hydroxy-2-methylbutanoic acid (2)
Asn-Trp (2)
Thr-Glu (2)
4-Hydroxyhippuric acid (2)
2-Undecanone (2)
DL-3-Phenyllactic acid (2)
Ribonic acid (2)
Ile-Thr (2)
Asp-Ile (2)
Leu-Thr (2)
Lactose (2)
Xylose (2)
Octadecanedioic acid (2)
8-HDoHE (2)
3-Oxocholic acid (2)
L-Saccharopine (2)
Levulinic acid (2)
Niacinamide (2)
L-Cysteine (2)
Guanine (2)
Betaine (2)
L-Alanine (2)

First Public Date

2023 (3)
2021 (3)
2014 (2)

Study type

Transcription profiling by array (1742)
RNA-seq of coding RNA (311)
ChIP-seq (127)
Comparative genomic hybridization by array (51)
Other (45)
ChIP-chip by array (42)
RNA-seq of non coding RNA (40)
Unknown experiment type (38)
RNA-seq of coding RNA from single cells (37)
ChIP-chip by tiling array (35)
Methylation profiling by array (35)
Methylation profiling by high throughput sequencing (27)
MicroRNA profiling by array (23)
RNA-seq of total RNA (23)
Transcription profiling by tiling array (18)
DNA-seq (14)
Animal - High-throughput sequencing (11)
Genotyping by array (11)
Cell line - High-throughput sequencing (9)
Transcription profiling by RT-PCR (9)
Human - High-throughput sequencing (8)
High-throughput sequencing (7)
RNAi profiling by array (5)
MicroRNA profiling by high throughput sequencing (4)
ATAC-seq (4)
Single nucleus RNA sequencing (4)
Animal - One-color microarray (3)
Hi-C (3)
Genotyping by high throughput sequencing (3)
Transcription profiling by SAGE (2)

Release Date

2010 (350)
2013 (317)
2012 (252)
2014 (245)
2011 (239)
2008 (225)
2015 (200)
2009 (166)
2007 (130)
2016 (126)
2005 (92)
2006 (77)
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2021 (58)
2018 (46)
2024 (41)
2004 (40)
2019 (39)
2017 (39)
2026 (31)
2003 (8)
2002 (5)
1999 (5)
1998 (4)
2000 (2)
2001 (1)
1997 (1)

Lab affiliation

1Department of Pharmacology, School of Medicine, University of California, San Diego, La Jolla, CA 92093 (1)
Assistant Professor Department of Chemisty University of South Florida Tampa, FL. USA. (1)
Brown University, MCB Department (1)
Chair of Biochemistry II, Theodor Boveri-Institute, Biocenter, University of Würzburg, Würzburg, Germany (1)
Department of Biochemistry, Western University, Canada (1)
Department of Chemistry & Chemical Biology, Northeastern University (1)
Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, RI, 02903 (1)
Department of Pharmacology & Toxicology 1 King’s College Circle Toronto, ON, Canada, M5S 1A8 (1)
Division of Protective Immunity Children’s Hospital of Philadelphia 816F ARC, 3615 Civic Center Boulevard Philadelphia, PA 19104 (1)
Institute for Systems Biology, Seattle, WA, USA (1)
Key Laboratory of Separation Sciences for Analytical Chemistry, National Chromatographic R&A Center, Dalian Institute of Chemical Physics, Chinese Academy of Sciences (CAS), Dalian 116023, China (1)
Northeastern University (1)

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Development of a Peptide Inhibitor Targeting the C-SH2 Domain of the SHP2 Phosphatase

Src homology 2 (SH2) domain-containing phosphatase 2 (SHP2) has important cellular functions in mediating signal transduction downstream of receptor tyrosine kinases and immune cell receptors. In T cells, SHP2 is a key regulator of signalling pathways downstream of the checkpoint receptor programmed...

ORGANISM(S): Homo sapiens (Human)

2025-05-09 | PXD054302 | Pride