Sort   by:  
 Page size 
TranscriptomicsShp2 Signaling Suppresses Senescence in PyMT-induced Mammary Gland Cancer in Mice [Mouse430A_2 array]
In this study, we have used techniques from cell biology, biochemistry, and genetics to investigate the role of the tyrosine phosphatase Shp2 in tumor cells of MMTV-PyMT mouse mammary glands. Genetic ablation or pharmacological inhibition of Shp2 induces senescence, as determined by the activation o...
ORGANISM(S): Mus musculus 
2015-03-06 | E-GEOD-50516 | biostudies-arrayexpress
TranscriptomicsPrimary TNBC tumor in the presence or absence of SHP2
The first bona fide PTP proto-oncogene was the Src-homology 2 domain-containing phosphatase SHP2 (encoded by PTPN11), an ubiquitously expressed PTP that transduces mitogenic, pro-survival, cell fate and/or pro-migratory signals from numerous growth factor-, cytokine- and extracellular matrix recepto...
ORGANISM(S): Homo sapiens 
2012-01-16 | E-GEOD-35118 | biostudies-arrayexpress
TranscriptomicsBT474 tumors in the presence or absence of SHP2
The first bona fide PTP proto-oncogene was the Src-homology 2 domain-containing phosphatase SHP2 (encoded by PTPN11), an ubiquitously expressed PTP that transduces mitogenic, pro-survival, cell fate and/or pro-migratory signals from numerous growth factor-, cytokine- and extracellular matrix recepto...
ORGANISM(S): Homo sapiens 
2011-12-20 | E-GEOD-34523 | biostudies-arrayexpress
ProteomicsSystematic Identification of SHP2 Phosphatase Substrates
Phosphatases play essential roles in normal cell physiology and diseases like cancer. The challenges of studying phosphatases have limited our understanding of their substrates, molecular mechanisms, and unique functions within highly complicate networks. Here we introduce a novel strategy using sub...
ORGANISM(S): Homo sapiens (Human) 
2022-09-20 | PXD028404 | Pride
Phosphoproteomics Tyrosine phosphatase substrates Lc-ms Shp2 
Proteomicsmyc-SHP2 IP to identify SHP2 interactors through proteomics IP
Missense mutations in PTPN11, which encodes the protein tyrosine phosphatase SHP2, are common in several developmental disorders and cancers. While many mutations disrupt auto-inhibition and hyperactivate SHP2, several do not enhance catalytic activity. Both activating and non-activating mutations c...
ORGANISM(S): Homo sapiens (Human) 
2025-08-31 | PXD067419 | Pride
Shp2 Ptp Ip Interactomics 
TranscriptomicsShp2 transcriptome in melanoma
1205Lu Metastatic Human melanoma cell lines with knockdown of Shp2 (PTPN11) were grown as xenograft tumors in NSG mice. RNA was extracted from the tumors and analyzed on [HuGene-2_0-st] Affymetrix Human Gene 2.0 ST Array [transcript (gene) version] Shp2 knockdown compared with non-target controls
ORGANISM(S): Homo sapiens 
2016-07-03 | E-GEOD-53282 | biostudies-arrayexpress
TranscriptomicsBT474 tumors and MCF10A-HER2/3 cells in the presence or absence of SHP2
This SuperSeries is composed of the following subset Series: GSE34523: BT474 tumors in the presence or absence of SHP2 GSE34524: MCF10A-HER2/3 cells grown in 3D cultures in the presence or absence of SHP2 Refer to individual Series
ORGANISM(S): Homo sapiens 
2011-12-20 | E-GEOD-34525 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of small intestinal gene expression of control and villinCre:Shp2fl mutant mice
Analysis of genes regulated by Shp2 mediated signaling in the small intestine Total RNA from small intestine of 6 villinCre;Shp2fl conditional mutant mice was compared to 6 control mice
ORGANISM(S): Mus musculus 
2014-02-24 | E-GEOD-50785 | biostudies-arrayexpress
ProteomicsSHP2 TurboID to identify SHP2 interactors and co-localized protein
Missense mutations in PTPN11, which encodes the protein tyrosine phosphatase SHP2, are common in several developmental disorders and cancers. While many mutations disrupt auto-inhibition and hyperactivate SHP2, several do not enhance catalytic activity. Both activating and non-activating mutations c...
ORGANISM(S): Homo sapiens (Human) 
2025-08-31 | PXD067905 | Pride
Shp2 Hek 293 cells Turboid Interactomics Protein-protein interactions 
ProteomicsSHP2 lysates to identify SHP2 interactors and co-localized protein (total proteome)
Missense mutations in PTPN11, which encodes the protein tyrosine phosphatase SHP2, are common in several developmental disorders and cancers. While many mutations disrupt auto-inhibition and hyperactivate SHP2, several do not enhance catalytic activity. Both activating and non-activating mutations c...
ORGANISM(S): Homo sapiens (Human) 
2025-10-08 | PXD069201 | Pride
Shp2 Hek 293 cells Turboid Phosphatase Total proteome Interactomics Protein-protein interactions 
Sort   by:  
 Page size