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TranscriptomicsTranscription profiling of human lung fibroblasts (HLF) treated with Cr(VI) a carcingogen in the presence of PTP to investigate the effect of protein tyrosine phosphatases inhibition on changes in gene expression
Although the consequences of genotoxic injury include cell cycle arrest and apoptosis, cell survival responses after genotoxic injury can produce intrinsic death-resistance and contribute to the development of a transformed phenotype. Protein tyrosine phosphatases (PTPs) are integral components of k...
ORGANISM(S): Homo sapiens 
2009-01-13 | E-GEOD-12205 | biostudies-arrayexpress
ProteomicsVE-PTP inhibition stabilizes endothelial junctions by activating FGD5
Inhibition of VE-PTP, an endothelial receptor type tyrosine phosphatase, triggers phosphorylation of the tyrosine kinase receptor Tie-2, which leads to the suppression of inflammation-induced vascular permeability. Analyzing the underlying mechanism, we show here that inhibition of VE-PTP and activa...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2019-05-04 | PXD010959 | Pride
Junctions Phosphatase Transmigration Signalling Ve-ptp Lc-msms Fgd5 Shotgun proteomics Inflammation Ptprb Tyrosine kinase receptor Adhesion Phosphorylation Endothelium 
ProteomicsComprehensive PTP and proteome profiling from human liver tissues
The extent to which PTP (Protein tyrosine phosphatase) expression may be evident and contribute to the progression to non-alcoholic fatty liver disease (NAFLD)/metabolic dysfunction-associated steatotic liver disease (MASLD) in obesity and the development of hepatocellular carcinoma (HCC) remains un...
ORGANISM(S): Homo sapiens (Human) 
2024-09-24 | PXD046940 | Pride
Ptp Hepatic proteome Hcc Steatosis Lc-ms/ms Nash 
TranscriptomicsmRNAs associated with EIF4E1 and EIF4E6 in Trypanosoma brucei
Trypanosomes expressing PTP-tagged EIF4E1 (PCF) or EIF4E6 (BSF) were used. The PTP-tagged proteins were purified on IgG columns, then eluted with TEV protease.
ORGANISM(S): Trypanosoma brucei brucei 
2021-05-22 | E-MTAB-10453 | biostudies-arrayexpress
TranscriptomicsPull-down of PTP-tagged EIF4E2 from bloodstream-form Trypanosoma brucei
Pull-down of PTP-tagged EIF4E2 from bloodstream-form Trypanosoma brucei, sequence of bound and unbound fractions
ORGANISM(S): Trypanosoma brucei brucei 
2021-08-31 | E-MTAB-10670 | biostudies-arrayexpress
ProteomicsSILAC analysis of ptp-3 knockout in C. elegans
A ptp-3 mutant and wildtype C. elegans were SILAC labeled and subjected to whole proteome analysis and phosphotyrosine enrichment.
ORGANISM(S): Caenorhabditis elegans 
2016-12-14 | PXD003233 | Pride
Phosoproteomics C. elegans Silac 
GenomicsStenotrophomonas maltophilia strain:ptp 12.25
Stenotrophomonas maltophilia strain:ptp 12.25 Genome sequencing and assembly
PRJNA560476 | ENA
GenomicsPull-down of PTP-tagged EIF4E2 from bloodstream-form Trypanosoma brucei
Pull-down of PTP-tagged EIF4E2 from bloodstream-form Trypanosoma brucei
PRJEB46062 | ENA
GenomicsInvestigation of the genetic basis of the rare syndrome Post-Transfusion Purpura (PTP)
The Post-Transfusion Pupura (PTP) syndrome although rare has severe side effects for 5-10 cases per annum in the UK as a result of transfusion. High quality DNA has been isolated from either whole blood or from cryopreserved mononuclear cells of 4 patients in order to study our postulation that the ...
EGAS00001000053 | EGA
Genomics
PTP-102
PRJNA1080359 | ENA
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