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TranscriptomicsRegulation of neuronal gene and miRNA expression by the complement protein C1q associated with neuroprotection
Identification of transcriptional profiles stimulated by the complement protein C1q in rat immature neurons associated with the C1q-dependent neuroprotection observed in vitro. Use of the unbiased whole genome microarray approach to identify genes regulated by C1q. Immature neurons grown in vitro fo...
ORGANISM(S): Rattus norvegicus 
2011-03-07 | E-GEOD-18860 | biostudies-arrayexpress
TranscriptomicsModulation of gene expression by complement protein C1q in amyloid-beta injured neurons
Complement protein C1q is induced after injury in the brain and during Alzheimer's disease and has been shown to protect against amyloid-beta induced neuronal death. In this study, we used microarray approach to identify the pathways modulated by C1q that are associated with neuroprotection. Immatur...
ORGANISM(S): Rattus norvegicus 
2012-12-21 | E-GEOD-28886 | biostudies-arrayexpress
TranscriptomicsExpression data from peripheral blood
C1q expression increases significantly in the peripheral blood of patients with active tuberculosis compared to healthy controls and individuals with latent TB infection. The percentage of C1q-expressing CD14 positive cells is significantly increased in active TB patients. C1q expression in the peri...
ORGANISM(S): Homo sapiens 
2014-02-15 | E-GEOD-54992 | biostudies-arrayexpress
TranscriptomicsComplement protein C1q modulates macrophage molecular signaling and inflammatory responses during ingestion of atherogenic lipoproteins
C1q suppresses JAK-STAT signal transduction and activates PPAR-mediated transcription in macrophages during clearance of modified forms of LDL leading to a reduction in inflammatory response. Human monocyte-derived macrophages (HMDM) were incubated with either oxidized (oxLDL) or acetylated low-dens...
ORGANISM(S): Homo sapiens 
2016-08-25 | E-GEOD-80442 | biostudies-arrayexpress
TranscriptomicsC1q elicited macrophage gene expression
We have data from a previous microarray experiment which shows that C1q elicits macrophages to express genes important for clearance of dead (apoptotic) cells. In this experiment we want to determine the signaling mechanism by which C1q is turning on macrophage gene expression. For our control (sam...
ORGANISM(S): Mus musculus 
2014-07-10 | E-GEOD-48619 | biostudies-arrayexpress
ProteomicsIgM Abs to Apoptosis-associated Determinants recruit C1q and enhance dendritic cell phagocytosis of apoptotic cells
Natural antibodies, which arise without known immune exposure, have been described that specifically recognize cells dying from apoptosis but their role in innate immunity remains poorly understood. Herein, we show that the immune response to neo-antigenic determinants on apoptotic thymocytes is dom...
ORGANISM(S): Mus musculus 
2009-02-23 | E-GEOD-14958 | biostudies-arrayexpress
ProteomicsC1Q labels a highly aggressive macrophage-like leukemia population indicating extramedullary infiltration and relapse
Extramedullary infiltration (EMI) is a concomitant manifestation indicating poor prognosis of acute myeloid leukemia (AML), yet the underlying mechanism remains poorly understood and therapeutic options are limited. Here, we employed single-cell RNA sequencing on bone marrow (BM) and EMI samples fro...
ORGANISM(S): Homo Sapiens 
PXD035784 |
GenomicsTranscriptome analysis of C1q-administrated murine lungs
Transcriptome analysis of C1q-administrated murine lungs
PRJNA764686 | ENA
ProteomicsSmall intestinal γδ T17 cells promote SAE through STING/C1q-induced microglial synaptic pruning
Sepsis is a severe global health issue with high mortality rates, and sepsis-associated encephalopathy (SAE) further exacerbates this risk. While recent studies have shown the migration of gut immune cells to the lungs after sepsis, their impact on the central nervous system remains unclear. Our res...
ORGANISM(S): Mus Musculus 
2024-10-28 | PXD057241 |
GenomicsC1q reprograms innate immune memory [RNA-seq]
C1q reprograms innate immune memory [RNA-seq]
PRJNA1130475 | ENA
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