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ProteomicsStructural Insights into Complement Inhibition: Visualizing Distinct Binding Modes of C4b-binding Protein Complexes with C4b and SAP
C4b-binding protein (C4BP) is an innate immune inhibitor found in serum. Human C4BP adopts spider-like higher-order structures (HOS) formed by disulfide-linked C4BPα and C4BPβ chains that non-covalently bind vitamin K-dependent protein S (ProS). These spider-like structures can form even larger comp...
ORGANISM(S): Homo sapiens (Human) 
2025-08-07 | PXD059888 | Pride
Mass photometry Complement regulation High-speed atomic force microscopy Serum amyloid p component. C4b-binding protein C4b Cross-linking mass spectrometry 
UnknownStructural Insights Into Complement Inhibition: Visualizing Distinct Binding Modes of C4b-Binding Protein Complexes With C4b and SAP.
Not available
S-EPMC12419116 | biostudies-literature
UnknownC4b-binding protein inhibits particulate- and crystalline-induced NLRP3 inflammasome activation.
Not available
S-EPMC10239802 | biostudies-literature
ProteomicsHigher-order structure and proteoforms of co-occurring C4b-binding protein assemblies in human serum
The complement is an evolutionarily conserved proteolytic cascade that plays a central role in the innate immune system. To maintain a delicate equilibrium preventing excessive complement activation, complement inhibitors are essential alongside complement activators. One of the major fluid-phase co...
ORGANISM(S): Homo sapiens (Human) 
2024-05-21 | PXD047679 | Pride
C4b-binding protein Mass spectrometry-based techniques Integrative structural modeling Complement 
UnknownNontypeable Haemophilus influenzae P5 Binds Human C4b-Binding Protein, Promoting Serum Resistance.
Not available
S-EPMC8428749 | biostudies-literature
UnknownThe Molecular Basis of Human IgG-Mediated Enhancement of C4b-Binding Protein Recruitment to Group A Streptococcus.
Not available
S-EPMC6557989 | biostudies-literature
UnknownThe pH-regulated antigen 1 of Candida albicans binds the human complement inhibitor C4b-binding protein and mediates fungal complement evasion.
Not available
S-EPMC3048689 | biostudies-literature
UnknownRecruitment of C4b-binding protein is not a complement evasion strategy employed by Staphylococcus aureus.
Not available
S-EPMC10569063 | biostudies-literature
UnknownC4b Binding Protein Acts as an Innate Immune Effector Against Influenza A Virus.
Not available
S-EPMC7820937 | biostudies-literature
UnknownConserved patterns hidden within group A Streptococcus M protein hypervariability recognize human C4b-binding protein.
Not available
S-EPMC5014329 | biostudies-literature
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