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ProteomicsStructural Insights into Complement Inhibition: Visualizing Distinct Binding Modes of C4b-binding Protein Complexes with C4b and SAP
C4b-binding protein (C4BP) is an innate immune inhibitor found in serum. Human C4BP adopts spider-like higher-order structures (HOS) formed by disulfide-linked C4BPα and C4BPβ chains that non-covalently bind vitamin K-dependent protein S (ProS). These spider-like structures can form even larger comp...
ORGANISM(S): Homo sapiens (Human) 
2025-08-07 | PXD059888 | Pride
Mass photometry Complement regulation High-speed atomic force microscopy Serum amyloid p component. C4b-binding protein C4b Cross-linking mass spectrometry 
GenomicsVibrio parahaemolyticus strain:C4B | isolate:C4B
Vibrio parahaemolyticus strain:C4B | isolate:C4B Genome sequencing and assembly
PRJNA606186 | ENA
ProteomicsComplement is activated by elevated IgG3 hexameric platforms and deposits C4b onto distinct antibody domains
IgG3 is unique among the IgG subclasses due to its extended hinge, allotypic diversity and enhanced effector functions, including highly efficient pathogen neutralization and complement activation. It is also underrepresented as an immunotherapeutic candidate, partly due to a lack of structural info...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD039049 | Pride
Igg Cryoem Igg3 
GenomicsERV-Derived RNA-DNA Hybrids Upregulate C4b to Induce Microglial Synaptic Pruning in autism [RNA]
ERV-Derived RNA-DNA Hybrids Upregulate C4b to Induce Microglial Synaptic Pruning in autism [RNA]
PRJNA1149734 | ENA
GenomicsERV-Derived RNA-DNA Hybrids Upregulate C4b to Induce Microglial Synaptic Pruning in autism [ChIP-seq]
ERV-Derived RNA-DNA Hybrids Upregulate C4b to Induce Microglial Synaptic Pruning in autism [ChIP-seq]
PRJNA1149674 | ENA
TranscriptomicsERV-Derived RNA-DNA Hybrids Upregulate C4b to Induce Microglial Synaptic Pruning in autism [RNA]
Microglia-mediated neuroinflammation has been identified as pathogenic in autism spectrum disorders (ASD). Pathogenic factors for microglial activation remain unclear. In our study, we discovered that complement C4b is highly expressed in the prefrontal cortex (PFC) neurons with SETDB1 deficiency, a...
ORGANISM(S): Mus musculus 
2026-02-24 | GSE275174 | GEO
GenomicsERV-Derived RNA-DNA Hybrids Upregulate C4b to Induce Microglial Synaptic Pruning in autism [ChIP-seq]
Microglia-mediated neuroinflammation has been identified as pathogenic in autism spectrum disorders (ASD). Pathogenic factors for microglial activation remain unclear. In our study, we discovered that complement C4b is highly expressed in the prefrontal cortex (PFC) neurons with SETDB1 deficiency, a...
ORGANISM(S): Mus musculus 
2026-02-24 | GSE275136 | GEO
TranscriptomicsHypothalamic gene expression profile indicates a reduction in G-protein signaling in the wfs1 mutant mice
WFS1 gene is coding protein with unknown function but its functional deficiency causes different neuropsychiatric and neuroendocrine syndromes. In the present study we aimed to find the functional networks influenced by the Wfs1 deficiency in the hypothalamus. We performed gene expression profiling ...
ORGANISM(S): Mus musculus 
2011-11-02 | E-GEOD-33372 | biostudies-arrayexpress
UnknownStructural Insights Into Complement Inhibition: Visualizing Distinct Binding Modes of C4b-Binding Protein Complexes With C4b and SAP.
Not available
S-EPMC12419116 | biostudies-literature
UnknownMultifaceted Activities of Seven Nanobodies against Complement C4b.
Not available
S-EPMC9047069 | biostudies-literature
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