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The Glycan CA19-9 Promotes Pancreatitis and Pancreatic Cancer In Mice
CA19-9 promotes liver metastasis of pancreatic cancer through E-selectin mediated extravasation
Pancreatic ductal adenocarcinoma (PDAC) frequently metastasizes to the liver, which drives patient mortality. CA19-9 is elevated in most PDAC tumors and is widely used as a clinical biomarker. Elevated serum levels are associated with poor outcomes. However, whether CA19-9 functionally contributes t...
ORGANISM(S): Mus musculus 
2026-09-04 | GSE341736 | GEO
Gene expression changes in normal pancreatic ductal organoids were isolated from mice with inducible expression of the glycan, CA19-9.
ORGANISM(S): Mus musculus 
2019-06-05 | GSE130854 | GEO
CA19-9 is a glycan elevated in human gastrointestinal pathologies, but absent from rodents. We humanized the mouse glycome and found that CA19-9 is not only a correlative biomarker of pancreatic disease, but also plays a causative role in the initiation of pancreatitis. Elevation of CA19-9 results i...
ORGANISM(S): Mus musculus (Mouse) 
2019-06-06 | PXD008564 | Pride
FUT3-dependent DDX21 fucosylation links elevated CA19-9 to pancreatic cancer metastasis via MIB2 alternative splicing and E-cadherin destabilization
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